BMP7 and ENG

Number of citations of the paper that reports this interaction (PubMedID 9872992)
0

Data Source:
HPRD (in vitro)

		BMP7	ENG
Description		bone morphogenetic protein 7	endoglin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding	Transmembrane Signaling Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Signaling Receptor Activator Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Eye Development Metanephros Development Ureteric Bud Development Mesoderm Formation Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Endocardial Cushion Formation Pericardium Morphogenesis Pattern Specification Process Axon Guidance Salivary Gland Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Dendrite Development Neural Fold Elevation Formation Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Hindbrain Development Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Tube Morphogenesis Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Embryonic Camera-type Eye Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cartilage Development Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Embryonic Skeletal Joint Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Cellular Response To BMP Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Brown Fat Cell Differentiation Cell-cell Adhesion Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Allantois Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Multicellular Organismal Development Regulation Of Removal Of Superoxide Radicals	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Heart Looping Sprouting Angiogenesis Positive Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Dorsal Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Atrial Cardiac Muscle Tissue Morphogenesis Cell Chemotaxis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Detection Of Hypoxia Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Molecules associated with elastic fibres Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs			Carotuximab
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Apolipoprotein A1 levels ( 32203549) Cerebrospinal P-tau181p levels ( 28247064) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Metopic nonsyndromic craniosynostosis ( 32266521) Microalbuminuria in type 1 diabetes ( 31537649) Monobrow ( 27182965) Nose size ( 27182965) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Response to citalopram treatment ( 19846067) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) White blood cell types ( 21738478)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148) Monocyte count ( 32888494)
Interacting Genes		32 interacting genes: ACTN4 ACVR1 ACVR2A ACVR2B BEGAIN BMPR1A BMPR1B BMPR2 CCDC125 CHRDL2 CRIPTO CYSRT1 ENG GDF7 KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-1 KRTAP5-9 KRTAP9-8 MTUS2 NBPF19 NCOA3 NOG NOTCH2NLA SOSTDC1 TRIM27	13 interacting genes: ACVR1 ACVR2A BMP2 BMP7 DYNLT4 GDF2 INHBA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		655	2022
HPRD ID		00212	00565
Ensembl ID		ENSG00000101144	ENSG00000106991
Uniprot IDs		A8K571 P18075	B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		1BMP 1LX5 1LXI 1M4U	5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway BMP Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Keratin Filament Intermediate Filament BMP Binding Cellular Response To BMP Stimulus Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Binding Positive Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Regionalization Pattern Specification Process Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Activity, Type I Mesoderm Development Regulation Of Ossification Response To Growth Factor Osteoblast Differentiation Outflow Tract Septum Morphogenesis Activin Receptor Complex Cardiac Septum Morphogenesis Mitral Valve Morphogenesis Tissue Development Anterior/posterior Pattern Specification Ventricular Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Endocardial Cushion Formation Receptor Complex Mesoderm Formation Morphogenesis Of An Epithelial Fold Gastrulation With Mouth Forming Second Animal Organ Morphogenesis Formation Of Primary Germ Layer Artery Morphogenesis Atrioventricular Valve Morphogenesis Dorsal/ventral Pattern Formation	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Animal Organ Development Type II Transforming Growth Factor Beta Receptor Binding Activin Receptor Signaling Pathway Activin Binding Type III Transforming Growth Factor Beta Receptor Binding Epithelial To Mesenchymal Transition Odontogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Mesenchymal Cell Differentiation Animal Organ Morphogenesis Transforming Growth Factor Beta Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Intracellular Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Differentiation Tissue Morphogenesis Heart Development Cardiac Septum Morphogenesis Gland Morphogenesis Growth Factor Activity Cellular Response To BMP Stimulus Positive Regulation Of Developmental Process Roof Of Mouth Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition BMP Signaling Pathway Tube Morphogenesis Salivary Gland Morphogenesis Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Secondary Palate Development Regulation Of Cell Differentiation Cytokine Activity Positive Regulation Of Signal Transduction
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