BMP7 and ACVR1

Number of citations of the paper that reports this interaction (PMID 8006002)
107

Data Source:
HPRD (in vivo)

		BMP7	ACVR1
Gene Name		bone morphogenetic protein 7	activin A receptor, type I
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Membrane-bounded Vesicle	Integral Component Of Plasma Membrane Apical Part Of Cell Activin Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Axon Guidance Embryonic Pattern Specification Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Growth Negative Regulation Of Phosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Cartilage Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Regulation Of Removal Of Superoxide Radicals	G1/S Transition Of Mitotic Cell Cycle Patterning Of Blood Vessels Urogenital System Development In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Mitral Valve Morphogenesis Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs			Adenosine triphosphate 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS		Response to citalopram treatment ( 19846067) White blood cell types ( 21738478)
Protein-Protein Interactions		21 interactors: ACTN4 ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 ENG GDF7 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP5-9 MTUS2 NCOA3 NOG NOTCH2NL SOSTDC1 TRIM27	64 interactors: AP2B1 BAMBI BMP2 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FCHO1 FGD6 FKBP4 FNTA GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		655	90
HPRD ID		00212	00021
Ensembl ID		ENSG00000101144	ENSG00000115170
Uniprot IDs		A8K571 P18075	D3DPA4 Q04771
PDB IDs		1BMP 1LX5 1LXI 1M4U	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Tissue Development Regulation Of Osteoblast Differentiation Pattern Specification Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Ossification Positive Regulation Of Ossification Embryonic Morphogenesis Organ Morphogenesis Tube Development Epithelium Development Mesoderm Development Skeletal System Development Enzyme Linked Receptor Protein Signaling Pathway Gastrulation Regulation Of Transcription From RNA Polymerase II Promoter Tissue Morphogenesis Tube Morphogenesis Regulation Of Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Differentiation Embryo Development Signal Transduction By Phosphorylation Organ Development Regulation Of Signaling Positive Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Phosphorylation Protein Phosphorylation Signal Transduction Developmental Process Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Signaling Cartilage Development Venous Blood Vessel Development Cell Communication Endothelial Cell Differentiation Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Intracellular Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Metabolic Process Response To Stimulus BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cell Differentiation Regulation Of Cellular Process Ras Protein Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Skeletal System Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Response To Organic Substance Positive Regulation Of Gene Expression Epithelium Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation
Tagcloud ?		antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Difference) ?		antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Intersection) ?