SKIV2L and EXOSC4

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		SKIV2L	EXOSC4
Gene Name		superkiller viralicidic activity 2-like (S. cerevisiae)	exosome component 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Ski Complex	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	RNA Binding ATP-dependent RNA Helicase Activity ATP Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725 20861866) Prostate cancer ( 23535732)
Protein-Protein Interactions		11 interactors: CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA SNRPB TNRC17 TSSK2 WDR1 XRN1	27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		6499	54512
HPRD ID		02724	16221
Ensembl ID		ENSG00000204351	ENSG00000178896
Uniprot IDs		Q15477	Q9NPD3
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Histone MRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process RRNA Catabolic Process RRNA Metabolic Process Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process NcRNA Metabolic Process MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay MRNA Metabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Cell Growth RRNA Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Regulation Of Growth Ribosome Biogenesis Cellular Metabolic Process Protein Autophosphorylation DNA Deamination Positive Regulation Of Growth Dosage Compensation By Inactivation Of X Chromosome Cellular Macromolecule Catabolic Process Intracellular MRNA Localization Dosage Compensation	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process
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