SKIC2 and GALNT13

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		SKIC2	GALNT13
Description		SKI2 subunit of superkiller complex	polypeptide N-acetylgalactosaminyltransferase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ski Complex	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease	O-linked glycosylation of mucins
Drugs
Diseases
GWAS			Aging traits ( 17903295) Blood trace element (Zn levels) ( 23720494) Body mass index ( 24348519) Coronary artery disease in type 1 diabetes ( 29695241) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Liver enzyme levels (alanine transaminase) ( 24124411) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Placental abruption ( 29884306) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Schizophrenia or schizoaffective disorder ( 31591465) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 WEE2-AS1 XRN1	2 interacting genes: EXOSC2 SKIC2
Entrez ID		6499	114805
HPRD ID		02724	16325
Ensembl ID		ENSG00000204351	ENSG00000144278
Uniprot IDs		A0A1U9X8J1 A0A8V8TLC0 H7C5N0 Q15477	A0A1L4BJA8 B3KY85 Q8IUC8
PDB IDs		7QDR 7QDS 7QDY 7QDZ 7QE0 9G8M 9G8N 9G8O 9G8P 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance Histone MRNA Catabolic Process Telomerase RNA Binding Histone MRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Maturation Of 5.8S RRNA U1 SnRNP Negative Regulation Of Telomere Maintenance Via Telomerase MRNA Catabolic Process Protein Serine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Serine/threonine Kinase Activity Regulation Of Membrane Repolarization Negative Regulation Of Telomere Maintenance Podosome Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization RNA Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Establishment Of Planar Polarity Of Follicular Epithelium Cellular Response To Puromycin Cellular Response To Cycloheximide Exonuclease Activity Protein Kinase Activity SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RRNA Metabolic Process Euchromatin Regulation Of Cell Morphogenesis Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of High Voltage-gated Calcium Channel Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Proline Dehydrogenase Activity	Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress MRNA Catabolic Process Ski Complex Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Nucleobase-containing Compound Catabolic Process 3'-5' RNA Helicase Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process U4 SnRNA 3'-end Processing Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Voltage-gated Sodium Channel Complex TRNA Decay Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Voltage-gated Sodium Channel Activity Sno(s)RNA Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Node Of Ranvier MRNA Metabolic Process SnRNA 3'-end Processing Neuronal Action Potential 3'-5'-RNA Exonuclease Activity Sodium Channel Activity Monoatomic Cation Channel Activity Rescue Of Stalled Ribosome SnRNA Processing Nuclear RNA Surveillance Cardiac Muscle Cell Action Potential Involved In Contraction Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Surveillance Cardiac Muscle Cell Action Potential Ribosome Disassembly Cellular Response To Osmotic Stress SnRNA Metabolic Process Macromolecule Catabolic Process Translational Elongation Response To Osmotic Stress Negative Regulation Of Gene Expression RNA Helicase Activity Organelle Disassembly RNA 3'-end Processing
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