SKIC2 and WDR1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		SKIC2	WDR1
Description		SKI2 subunit of superkiller complex	WD repeat domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ski Complex	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome	Neutrophil Mediated Immunity Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Platelet Formation Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Cortical Cytoskeleton Organization Locomotion Establishment Of Planar Polarity Of Follicular Epithelium Apical Junction Assembly Maintenance Of Epithelial Cell Apical/basal Polarity Sarcomere Organization Regulation Of Oligodendrocyte Differentiation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neutrophil Migration
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease	Platelet degranulation
Drugs
Diseases
GWAS			Atrial fibrillation ( 29892015) Cardiovascular disease risk factors ( 21943158) Cleft plate (environmental tobacco smoke interaction) ( 24516586) Estimated glomerular filtration rate ( 31152163) Gout ( 33832965) Pulse pressure ( 30224653) Schizophrenia (age at onset) ( 21688384) Serum uric acid levels ( 32514006) Urate levels ( 18179892 31578528) Uric acid levels ( 22229870)
Interacting Genes		15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 WEE2-AS1 XRN1	6 interacting genes: CARD11 CFL1 CSNK2B GRB2 HSPB2 SKIC2
Entrez ID		6499	9948
HPRD ID		02724	09199
Ensembl ID		ENSG00000204351	ENSG00000071127
Uniprot IDs		A0A1U9X8J1 A0A8V8TLC0 H7C5N0 Q15477	A0A8V8TP22 O75083 V9HWG7
PDB IDs		7QDR 7QDS 7QDY 7QDZ 7QE0 9G8M 9G8N 9G8O 9G8P 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance Histone MRNA Catabolic Process Telomerase RNA Binding Histone MRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Maturation Of 5.8S RRNA U1 SnRNP Negative Regulation Of Telomere Maintenance Via Telomerase MRNA Catabolic Process Protein Serine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Serine/threonine Kinase Activity Regulation Of Membrane Repolarization Negative Regulation Of Telomere Maintenance Podosome Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization RNA Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Establishment Of Planar Polarity Of Follicular Epithelium Cellular Response To Puromycin Cellular Response To Cycloheximide Exonuclease Activity Protein Kinase Activity SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RRNA Metabolic Process Euchromatin Regulation Of Cell Morphogenesis Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of High Voltage-gated Calcium Channel Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Proline Dehydrogenase Activity	Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Tissue Morphogenesis Positive Regulation Of Barbed-end Actin Filament Capping Morphogenesis Of An Epithelium Positive Regulation Of Protein Localization To Cell Leading Edge Guanyl-nucleotide Exchange Factor Adaptor Activity T Cell Costimulation Positive Regulation Of Cell Adhesion Protein Phosphatase Binding Negative Regulation Of Postsynaptic Density Organization Grb2-EGFR Complex Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Protein Localization To Cell Leading Edge Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Neural Fold Formation Actin Filament Fragmentation Somatic Muscle Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Release From Viral Latency CBM Complex Regulation Of Cell Adhesion Cell-cell Junction Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Neurotrophin TRKA Receptor Binding Intracellular Signaling Cassette Protein-macromolecule Adaptor Activity Extracellular Exosome Protein Domain Specific Binding 3'-5' RNA Helicase Activity Adiponectin-activated Signaling Pathway Negative Regulation Of Cell Size Regulation Of Cellular Component Size GMP Kinase Activity CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Synaptic Plasticity Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction
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