SKIC2 and CDKL5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SKIC2	CDKL5
Name		SKI2 subunit of superkiller complex	cyclin dependent kinase like 5
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ski Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Dendritic Growth Cone Ciliary Tip Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Protein Serine Kinase Activity
	Biological Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome	Neuron Migration Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Axon Extension Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Cell Cycle Regulation Of Postsynapse Organization Regulation Of Cilium Assembly
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease	None
Diseases		None	Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		No GWAS studies recorded	Estimated glomerular filtration rate ( 31015462 )
Novel Interactors		1 novel interactors: PRODH	None recorded
Interacting Genes		15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 WEE2-AS1 XRN1	4 interacting genes: MLH1 SKIC2 SPTBN4 TACC3
Entrez ID		6499	6792
HPRD ID		02724	02190
Ensembl ID		ENSG00000204351	ENSG00000008086
Uniprot IDs		A0A1U9X8J1 A0A8V8TLC0 H7C5N0 Q15477	O76039
PDB IDs		7QDR 7QDS 7QDY 7QDZ 7QE0 9G8M 9G8N 9G8O 9G8P 9G8Q 9G8R	4BGQ 8CIE
GO Terms Enriched among Interactors		Nuclear MRNA Surveillance Histone MRNA Catabolic Process Telomerase RNA Binding Histone MRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Maturation Of 5.8S RRNA U1 SnRNP Negative Regulation Of Telomere Maintenance Via Telomerase MRNA Catabolic Process Protein Serine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Serine/threonine Kinase Activity Regulation Of Membrane Repolarization Negative Regulation Of Telomere Maintenance Podosome Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization RNA Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Establishment Of Planar Polarity Of Follicular Epithelium Cellular Response To Puromycin Cellular Response To Cycloheximide Exonuclease Activity Protein Kinase Activity SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RRNA Metabolic Process Euchromatin Regulation Of Cell Morphogenesis Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of High Voltage-gated Calcium Channel Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Proline Dehydrogenase Activity	Organelle Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment RNA Catabolic Process Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule Mismatch Repair Complex MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Cytoskeletal Protein-membrane Anchor Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination 3'-5' RNA Helicase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Hillock Cell Body Fiber Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Metaphase/anaphase Transition Of Cell Cycle Telomere Localization Paranode Region Of Axon Spectrin Nucleobase-containing Compound Catabolic Process Spindle Midzone Assembly ATP Hydrolysis Activity Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Negative Regulation Of Heart Rate Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates Organelle Localization ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Node Of Ranvier