SKIC2 and CACNB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SKIC2	CACNB3
Description		SKI2 subunit of superkiller complex	calcium voltage-gated channel auxiliary subunit beta 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ski Complex	Cytoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport T Cell Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS
Interacting Genes		15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 WEE2-AS1 XRN1	11 interacting genes: CACNA1B CACNA1C CEP76 CIMIP1 CTBP2 FASLG GEM MEOX1 MTUS2 SKIC2 SYT1
Entrez ID		6499	784
HPRD ID		02724	11879
Ensembl ID		ENSG00000204351	ENSG00000167535
Uniprot IDs		A0A1U9X8J1 A0A8V8TLC0 H7C5N0 Q15477	P54284
PDB IDs		7QDR 7QDS 7QDY 7QDZ 7QE0 9G8M 9G8N 9G8O 9G8P 9G8Q 9G8R	7MIX 7MIY 7UHF 7UHG 8E59 8E5A 8E5B 8EPL 8FHS 8WE6 8WE7 8WE8 8WE9 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance Histone MRNA Catabolic Process Telomerase RNA Binding Histone MRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Maturation Of 5.8S RRNA U1 SnRNP Negative Regulation Of Telomere Maintenance Via Telomerase MRNA Catabolic Process Protein Serine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Serine/threonine Kinase Activity Regulation Of Membrane Repolarization Negative Regulation Of Telomere Maintenance Podosome Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization RNA Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Establishment Of Planar Polarity Of Follicular Epithelium Cellular Response To Puromycin Cellular Response To Cycloheximide Exonuclease Activity Protein Kinase Activity SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RRNA Metabolic Process Euchromatin Regulation Of Cell Morphogenesis Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of High Voltage-gated Calcium Channel Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Proline Dehydrogenase Activity	Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transmembrane Import Into Cytosol High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Neurotransmitter Secretion Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Calcium Ion Import Calcium Ion Transmembrane Transport Calmodulin Binding Regulation Of Calcium Ion-dependent Exocytosis Metal Ion Transport Calcium Ion Transport Positive Regulation Of Regulated Secretory Pathway Regulation Of Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell Communication Monoatomic Cation Transport Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Calcium Channel Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of Exocytosis Inorganic Cation Import Across Plasma Membrane Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Positive Regulation Of Chromatin Organization Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Sclerotome Development Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Syntaxin-3 Binding Cytoplasmic Vesicle Lumen Monoatomic Ion Transport X Chromosome
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