BMI1 and LRIF1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BMI1	LRIF1
Description		BMI1 proto-oncogene, polycomb ring finger	ligand dependent nuclear receptor interacting factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	Chromosome, Telomeric Region Barr Body Nucleus Nucleoplasm Chromosome Nuclear Matrix Centriolar Satellite
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding RING-like Zinc Finger Domain Binding Ubiquitin-protein Transferase Activator Activity Promoter-specific Chromatin Binding	Protein Binding Nuclear Retinoic Acid Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Gene Expression, Epigenetic Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus Regulation Of Kidney Development Apoptotic Signaling Pathway Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases		Penile cancer
GWAS		Prostate-specific antigen levels ( 28139693)	Bone mineral content ( 31790847) Intraocular pressure ( 30591961)
Interacting Genes		45 interacting genes: CASC9 CBX8 CEP126 CSNK2B DEFA5 E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H2BC3 H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RBM22 RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	143 interacting genes: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BANP BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRACR2A CRADD CRCP CRCT1 CRIPTO DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FHL2 FOSL2 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 H3-4 HAP1 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NOC2L NR3C1 NRBP1 NTAQ1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR1C POLR2C POLR3F PPARG PQBP1 PRKAB2 PRKAR2A PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SNU13 SPATA18 SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSEN15 TSPAN6 UBE2V2 UNC119 VIM VPS26C WDR62 WWC1 ZNF24 ZNF410
Entrez ID		648	55791
HPRD ID		01277	17975
Ensembl ID		ENSG00000168283	ENSG00000121931
Uniprot IDs		P35226	Q5T3J3
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Chromatin Remodeling Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Structural Constituent Of Chromatin Chromosome Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Protein Modification Process Nucleoplasm Sex Chromatin Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Chromatin Binding Nucleus Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Heterochromatin Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MLL1 Complex Developmental Process Involved In Reproduction Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II PML Body Protein Metabolic Process Ubiquitin-protein Transferase Activator Activity Protein Heterodimerization Activity Zinc Ion Binding Nuclear Body Response To Ionizing Radiation Signal Transduction In Response To DNA Damage	Nucleus Nucleoplasm Protein Binding Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Binding Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Nuclear Receptor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Apoptotic Process Nucleolus Negative Regulation Of Transcription By RNA Polymerase II Biological_process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Development Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Hemopoiesis Chromatin Organization Regulation Of Cell Differentiation Mononuclear Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation DNA-directed RNA Polymerase Activity Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Cycle Process Regulation Of DNA Repair Regulation Of Cell Cycle G1/S Phase Transition
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