BMI1 and IMMT

Number of citations of the paper that reports this interaction (PubMedID 24457600)
57

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		BMI1	IMMT
Description		BMI1 proto-oncogene, polycomb ring finger	inner membrane mitochondrial protein
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	SAM Complex Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding RING-like Zinc Finger Domain Binding Ubiquitin-protein Transferase Activator Activity Promoter-specific Chromatin Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Gene Expression, Epigenetic Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus Regulation Of Kidney Development Apoptotic Signaling Pathway Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	Inner Mitochondrial Membrane Organization Cristae Formation Mitochondrial Calcium Ion Homeostasis Neuron Cellular Homeostasis
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Cristae formation
Drugs
Diseases		Penile cancer
GWAS		Prostate-specific antigen levels ( 28139693)	Facial emotion recognition (sad faces) ( 28608620) Night sleep phenotypes ( 27126917)
Interacting Genes		45 interacting genes: CASC9 CBX8 CEP126 CSNK2B DEFA5 E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H2BC3 H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RBM22 RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	65 interacting genes: AKTIP ALB ANTKMT ARMCX3 ASCC2 ATXN1 BAG6 BMI1 C10orf88 C8orf33 CALM1 CCT5 CDC37 CFAP263 CHD3 CSTF2 DISC1 DSCR9 ECSIT EEF1A1 EP300 EXOSC10 FEZ1 FUBP1 HAP1 HIVEP1 HJURP HMOX2 HNRNPD HTRA2 KDM1A KIF22 KPNA2 LRIF1 MARCHF5 MRPL44 NDEL1 NDUFB9 NEK2 NIPSNAP3A NOS3 NRIP1 PDE4B PFDN1 PIAS4 PLA2G15 PPOX PRRC2A RER1 RNF10 RNF26 SDHAF2 SMN1 SNAPIN SRRT STMN4 STX5 TAF1D TK1 TNNT1 TRAF3IP1 TUBGCP3 TXNDC9 UBC UBQLN4
Entrez ID		648	10989
HPRD ID		01277	02658
Ensembl ID		ENSG00000168283	ENSG00000132305
Uniprot IDs		P35226	B4DS66 C9J406 Q16891
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Chromatin Remodeling Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Structural Constituent Of Chromatin Chromosome Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Protein Modification Process Nucleoplasm Sex Chromatin Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Chromatin Binding Nucleus Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Heterochromatin Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MLL1 Complex Developmental Process Involved In Reproduction Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II PML Body Protein Metabolic Process Ubiquitin-protein Transferase Activator Activity Protein Heterodimerization Activity Zinc Ion Binding Nuclear Body Response To Ionizing Radiation Signal Transduction In Response To DNA Damage	Centrosome Cytoplasm Cytosol Microtubule-based Process Protein Binding Protein-containing Complex Nucleoplasm Organelle Organization Retrograde Axonal Transport Axon Cytoplasm Axonal Transport Synaptic Vesicle Nucleus Organelle Localization Cytoskeleton Internal Peptidyl-lysine Acetylation Mitochondrion Microtubule Gamma-tubulin Binding Axo-dendritic Transport Organelle Transport Along Microtubule Negative Regulation Of Macroautophagy Radial Glia-guided Pyramidal Neuron Migration Protein Localization To Perinuclear Region Of Cytoplasm Nuclear Body Regulation Of Protein Metabolic Process RNA Binding Regulation Of Organelle Transport Along Microtubule Transport Along Microtubule Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Telomere Maintenance Via Telomerase Kinesin Complex Vesicle Transport Along Microtubule Regulation Of Metabolic Process Negative Regulation Of Autophagy Catabolic Process Gamma-tubulin Complex Regulation Of Telomere Maintenance Centrosome Separation Unfolded Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Cytoskeleton-dependent Intracellular Transport
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