BMI1 and TUSC3

Number of citations of the paper that reports this interaction (PubMedID 19451220)
43

Data Source:
BioGRID (pull down)

		BMI1	TUSC3
Description		BMI1 proto-oncogene, polycomb ring finger	tumor suppressor candidate 3
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding RING-like Zinc Finger Domain Binding Ubiquitin-protein Transferase Activator Activity Promoter-specific Chromatin Binding	Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Gene Expression, Epigenetic Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus Regulation Of Kidney Development Apoptotic Signaling Pathway Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	Protein Glycosylation Protein N-linked Glycosylation Magnesium Ion Transport Protein N-linked Glycosylation Via Asparagine Cognition Transmembrane Transport Magnesium Ion Transmembrane Transport
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Asparagine N-linked glycosylation Miscellaneous transport and binding events Maturation of spike protein PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases		Penile cancer	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Prostate-specific antigen levels ( 28139693)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Intelligence ( 22449649) Metabolite levels ( 23823483) Methamphetamine dependence ( 23594818) Prudent dietary pattern ( 28644415) Pulmonary function decline ( 22424883) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to SSRI in MDD or openness ( 29559929)
Interacting Genes		45 interacting genes: CASC9 CBX8 CEP126 CSNK2B DEFA5 E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H2BC3 H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RBM22 RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	2 interacting genes: BMI1 PPP1CA
Entrez ID		648	7991
HPRD ID		01277	03228
Ensembl ID		ENSG00000168283	ENSG00000104723
Uniprot IDs		P35226	D6RA37 D6RIY7 Q13454
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG	4M8G 4M90 4M91 4M92
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Chromatin Remodeling Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Structural Constituent Of Chromatin Chromosome Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Protein Modification Process Nucleoplasm Sex Chromatin Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Chromatin Binding Nucleus Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Heterochromatin Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MLL1 Complex Developmental Process Involved In Reproduction Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II PML Body Protein Metabolic Process Ubiquitin-protein Transferase Activator Activity Protein Heterodimerization Activity Zinc Ion Binding Nuclear Body Response To Ionizing Radiation Signal Transduction In Response To DNA Damage	RING-like Zinc Finger Domain Binding Regulation Of Adaxial/abaxial Pattern Formation Regulation Of Apoptotic Signaling Pathway Rostrocaudal Neural Tube Patterning Cell Division Positive Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Ubiquitin-protein Transferase Activator Activity Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Somatic Stem Cell Division Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Ubiquitin-protein Transferase Activity Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Segment Specification PRC1 Complex Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of Glycogen Biosynthetic Process Response To Lead Ion Entrainment Of Circadian Clock By Photoperiod Regulation Of Translation In Response To Stress Negative Regulation Of Transcription Elongation By RNA Polymerase II Stem Cell Division Regulation Of Ubiquitin-protein Transferase Activity Protein Phosphatase 1 Binding Negative Regulation Of DNA-templated Transcription, Elongation PcG Protein Complex Photoperiodism Entrainment Of Circadian Clock Cellular Response To Dexamethasone Stimulus Regulation Of Glycogen Biosynthetic Process Regulation Of Kidney Development DNA Methylation-dependent Constitutive Heterochromatin Formation Positive Regulation Of Protein-containing Complex Disassembly Ribonucleoprotein Complex Binding Regulation Of Glycogen Metabolic Process Response To Dexamethasone Positive Regulation Of B Cell Proliferation Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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