BMI1 and PCBP2-OT1

Number of citations of the paper that reports this interaction (PubMedID 27154519)
0

Data Source:
BioGRID (unspecified method)

		BMI1	PCBP2-OT1
Description		BMI1 proto-oncogene, polycomb ring finger	PCBP2 overlapping transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding RING-like Zinc Finger Domain Binding Ubiquitin-protein Transferase Activator Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Gene Expression, Epigenetic Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus Regulation Of Kidney Development Apoptotic Signaling Pathway Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases		Penile cancer
GWAS		Prostate-specific antigen levels ( 28139693)
Interacting Genes		45 interacting genes: CASC9 CBX8 CEP126 CSNK2B DEFA5 E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H2BC3 H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RBM22 RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	1 interacting genes: BMI1
Entrez ID		648	102157401
HPRD ID		01277
Ensembl ID		ENSG00000168283	ENSG00000282977
Uniprot IDs		P35226
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Chromatin Remodeling Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Structural Constituent Of Chromatin Chromosome Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Protein Modification Process Nucleoplasm Sex Chromatin Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Chromatin Binding Nucleus Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Heterochromatin Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MLL1 Complex Developmental Process Involved In Reproduction Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II PML Body Protein Metabolic Process Ubiquitin-protein Transferase Activator Activity Protein Heterodimerization Activity Zinc Ion Binding Nuclear Body Response To Ionizing Radiation Signal Transduction In Response To DNA Damage	RING-like Zinc Finger Domain Binding Regulation Of Adaxial/abaxial Pattern Formation Rostrocaudal Neural Tube Patterning Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Ubiquitin-protein Transferase Activator Activity Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Ubiquitin-protein Transferase Activity Segment Specification PRC1 Complex Stem Cell Division PcG Protein Complex Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Dexamethasone Stimulus Regulation Of Kidney Development DNA Methylation-dependent Constitutive Heterochromatin Formation Embryonic Skeletal System Development Cellular Response To Interleukin-1 Positive Regulation Of Fibroblast Proliferation Cellular Response To Glucocorticoid Stimulus Response To Dexamethasone Heterochromatin Constitutive Heterochromatin Formation Positive Regulation Of B Cell Proliferation Regulation Of B Cell Proliferation Cellular Response To Corticosteroid Stimulus Promoter-specific Chromatin Binding Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Embryonic Skeletal System Morphogenesis Positive Regulation Of B Cell Activation Regulation Of Fibroblast Proliferation Ubiquitin Ligase Complex Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Ubiquitination Skeletal System Morphogenesis Embryonic Organ Morphogenesis Positive Regulation Of Post-translational Protein Modification Regulation Of B Cell Activation Response To Glucocorticoid Heterochromatin Formation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Corticosteroid Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Leukocyte Proliferation Hemopoiesis Regulation Of T Cell Proliferation Skeletal System Development
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