TBC1D15 and TAX1BP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology, affinity chromatography technology)

		TBC1D15	TAX1BP1
Description		TBC1 domain family member 15	Tax1 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Cytosol Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Zinc Ion Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Metal Ion Binding
	Biological Process	Regulation Of GTPase Activity Regulation Of Cilium Assembly	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagy Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein K48-linked Ubiquitination Protein Localization To Phagocytic Vesicle Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		TBC/RABGAPs	Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)	Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C TAX1BP1 UBC	72 interacting genes: ARHGAP1 ARK2N AZI2 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN ENTREP1 FAM161A FAM168A FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LITAF LMO3 LNX1 LRATD2 MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RIPK1 RNF11 RNF26 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446
Entrez ID		64786	8887
HPRD ID		15470	05618
Ensembl ID		ENSG00000121749	ENSG00000106052
Uniprot IDs		A8K8E1 Q8TC07	B4DSG5 Q86VP1
PDB IDs			2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G 8W6A 8W6B
Enriched GO Terms of Interacting Partners?		Plasma Membrane To Endosome Transport GDP Binding Endocytic Vesicle G Protein Activity Melanosome Early Endosome Membrane Establishment Of Protein Localization Endomembrane System Endosomal Transport Endosome Early Endosome GTPase Activity GTP Binding Endosome Organization Autophagosome Intracellular Protein Localization Protein Localization To Phagocytic Vesicle Negative Regulation Of Canonical NF-kappaB Signal Transduction Endocytosis Protein Transport Protein Localization To Early Endosome Response To Flavonoid Cytoplasmic Side Of Early Endosome Membrane Vesicle-mediated Transport Extracellular Exosome Synaptic Vesicle Membrane Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Negative Regulation Of Receptor Recycling Type 2 Mitophagy Response To Fluoride Response To Hypobaric Hypoxia Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Protein Localization To Organelle Import Into Cell Amyloid-beta Clearance By Transcytosis Innate Immune Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Xenophagy Molecular Adaptor Activity Negative Regulation Of Fatty Acid Transport Cellular Response To Peptide Negative Regulation Of Protein Polyubiquitination Regulation Of Endosome Size Cytosol Cellular Localization Organelle Organization Mitochondrial Outer Membrane	Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein Binding Autophagosome Autophagosome Maturation Protein-containing Complex Disassembly Autophagosome Membrane Cytoplasm Modification-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Tag Activity Autophagy GABA Receptor Binding Autophagosome Assembly Regulation Of Canonical NF-kappaB Signal Transduction Macroautophagy Autophagosome Organization Mitophagy Ubiquitin Protein Ligase Activity Cellular Response To Starvation WW Domain Binding Post-translational Protein Modification Protein Ubiquitination Autophagy Of Mitochondrion Catabolic Process Regulation Of Protein Modification Process Signaling Adaptor Activity Response To Starvation Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Beta-tubulin Binding Regulation Of Primary Metabolic Process Cellular Response To Nutrient Levels Organelle Assembly Vacuole Organization Identical Protein Binding Zinc Ion Binding Cytosol Positive Regulation Of Protein Modification Process
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