TBC1D15 and RAB5A

Number of citations of the paper that reports this interaction (PMID 16923123)
31

Data Source:
BioGRID (two hybrid)

		TBC1D15	RAB5A
Gene Name		TBC1 domain family, member 15	RAB5A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Extracellular Vesicular Exosome	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Rab GTPase Activator Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding
	Biological Process	Regulation Of Rab GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Cilium Assembly	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C	41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL
Entrez ID		64786	5868
HPRD ID		15470	01542
Ensembl ID		ENSG00000121749	ENSG00000144566
Uniprot IDs		Q8TC07	B4DJA5 P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH
Enriched GO Terms of Interacting Partners?		Cytoplasmic Transport Rab Protein Signal Transduction Plasma Membrane To Endosome Transport Intracellular Protein Transport Cellular Protein Localization Protein Transport Regulation Of Endocytosis Establishment Of Protein Localization Intracellular Transport Endosomal Transport Ras Protein Signal Transduction Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Cellular Response To Stimulus Cellular Localization Vesicle-mediated Transport G2/M Transition Of Mitotic Cell Cycle Small GTPase Mediated Signal Transduction Response To Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Autophagy Negative Regulation Of Receptor Recycling Regulation Of Cellular Component Organization Golgi Ribbon Formation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Mitochondrial Fission Mitochondrial Fragmentation Involved In Apoptotic Process Wnt Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Peroxisome Fission Centriole Replication Regulation Of Mitochondrial Fission Calcium-mediated Signaling Using Intracellular Calcium Source Establishment Of Protein Localization To Organelle Mitochondrial Calcium Ion Homeostasis Mitochondrial Fusion Transport Early Endosome To Late Endosome Transport Centriole Assembly Protein Targeting Endomembrane System Organization Protein Targeting To Golgi	Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion
Tagcloud ?		abuse causally cd133 cd49f chemoresistance demonstration deprivation ectopically elusive hcv heightens igf2bp3 initiating linking nanog ns5a numb nutrient obligatory oncoprotein predisposes renewal reprogramming synergism synergistically tics tlr4 tumorigenic yap1	accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Difference) ?		abuse causally cd133 cd49f chemoresistance demonstration deprivation ectopically elusive hcv heightens igf2bp3 initiating linking nanog ns5a numb nutrient obligatory oncoprotein predisposes renewal reprogramming synergism synergistically tics tlr4 tumorigenic yap1	accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Intersection) ?