TBC1D15 and OPTN

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TBC1D15	OPTN
Gene Name		TBC1 domain family, member 15	optineurin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Extracellular Vesicular Exosome	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Rab GTPase Activator Activity Protein Binding	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Regulation Of Rab GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Cilium Assembly	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation
Pathways			G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		7 interactors: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C	36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670
Entrez ID		64786	10133
HPRD ID		15470	03891
Ensembl ID		ENSG00000121749	ENSG00000123240
Uniprot IDs		Q8TC07	Q96CV9
PDB IDs			2LO4 2LUE 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Cytoplasmic Transport Rab Protein Signal Transduction Plasma Membrane To Endosome Transport Intracellular Protein Transport Cellular Protein Localization Protein Transport Regulation Of Endocytosis Establishment Of Protein Localization Intracellular Transport Endosomal Transport Ras Protein Signal Transduction Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Cellular Response To Stimulus Cellular Localization Vesicle-mediated Transport G2/M Transition Of Mitotic Cell Cycle Small GTPase Mediated Signal Transduction Response To Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Autophagy Negative Regulation Of Receptor Recycling Regulation Of Cellular Component Organization Golgi Ribbon Formation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Mitochondrial Fission Mitochondrial Fragmentation Involved In Apoptotic Process Wnt Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Peroxisome Fission Centriole Replication Regulation Of Mitochondrial Fission Calcium-mediated Signaling Using Intracellular Calcium Source Establishment Of Protein Localization To Organelle Mitochondrial Calcium Ion Homeostasis Mitochondrial Fusion Transport Early Endosome To Late Endosome Transport Centriole Assembly Protein Targeting Endomembrane System Organization Protein Targeting To Golgi	Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction
Tagcloud ?		abuse causally cd133 cd49f chemoresistance demonstration deprivation ectopically elusive hcv heightens igf2bp3 initiating linking nanog ns5a numb nutrient obligatory oncoprotein predisposes renewal reprogramming synergism synergistically tics tlr4 tumorigenic yap1	advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Difference) ?		abuse causally cd133 cd49f chemoresistance demonstration deprivation ectopically elusive hcv heightens igf2bp3 initiating linking nanog ns5a numb nutrient obligatory oncoprotein predisposes renewal reprogramming synergism synergistically tics tlr4 tumorigenic yap1	advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Intersection) ?