TBC1D15 and RAB5B

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		TBC1D15	RAB5B
Description		TBC1 domain family member 15	RAB5B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding
	Biological Process	Regulation Of GTPase Activity Regulation Of Cilium Assembly	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways		TBC/RABGAPs	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
Drugs
Diseases
GWAS		Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 30566500 22885925) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		9 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C TAX1BP1 UBC	19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		64786	5869
HPRD ID		15470	01544
Ensembl ID		ENSG00000121749	ENSG00000111540
Uniprot IDs		A8K8E1 Q8TC07	P61020
PDB IDs			2HEI
Enriched GO Terms of Interacting Partners?		Plasma Membrane To Endosome Transport GDP Binding Endocytic Vesicle G Protein Activity Melanosome Early Endosome Membrane Establishment Of Protein Localization Endomembrane System Endosomal Transport Endosome Early Endosome GTPase Activity GTP Binding Endosome Organization Autophagosome Intracellular Protein Localization Protein Localization To Phagocytic Vesicle Negative Regulation Of Canonical NF-kappaB Signal Transduction Endocytosis Protein Transport Protein Localization To Early Endosome Response To Flavonoid Cytoplasmic Side Of Early Endosome Membrane Vesicle-mediated Transport Extracellular Exosome Synaptic Vesicle Membrane Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Negative Regulation Of Receptor Recycling Type 2 Mitophagy Response To Fluoride Response To Hypobaric Hypoxia Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Protein Localization To Organelle Import Into Cell Amyloid-beta Clearance By Transcytosis Innate Immune Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Xenophagy Molecular Adaptor Activity Negative Regulation Of Fatty Acid Transport Cellular Response To Peptide Negative Regulation Of Protein Polyubiquitination Regulation Of Endosome Size Cytosol Cellular Localization Organelle Organization Mitochondrial Outer Membrane	Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport
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