PDLIM2 and ACD

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		PDLIM2	ACD
Description		PDZ and LIM domain 2	ACD shelterin complex subunit and telomerase recruitment factor
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Adherens Junction Z Disc Filamentous Actin	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Muscle Alpha-actinin Binding	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Protein Catabolic Process Muscle Structure Development	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Parkinson's disease ( 28892059) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Survival in breast cancer (estrogen-receptor positive) ( 29423119)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: ACD APC AURKA BAG4 BCAR3 FGFR2 FGFR4 MKRN2 POT1 RAF1 TGFB1 UBC UBE2E2 ZNF695	64 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		64236	65057
HPRD ID		17831	12417
Ensembl ID		ENSG00000120913	ENSG00000102977
Uniprot IDs		Q96JY6	A0A8Q3WM11 Q96AP0
PDB IDs		2PA1 3PDV	2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Activity Telomerase Inhibitor Activity Shelterin Complex Telomere Assembly Establishment Of Protein Localization To Telomere Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Insulin Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Branch Elongation Of An Epithelium Gland Development Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Fibroblast Migration Telomere Capping Ubiquitin Protein Ligase Binding Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Protein-containing Complex Binding Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Metabolic Process Protein Modification Process Fibroblast Growth Factor Binding Protein Phosphorylation Protein Autophosphorylation Positive Regulation Of Cell Cycle Axis Elongation Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Developmental Growth Involved In Morphogenesis Regulation Of Extracellular Matrix Disassembly RNA-templated DNA Biosynthetic Process Regulation Of Organelle Organization Phosphorylation	Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding
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