PDLIM2 and MKRN2

Number of citations of the paper that reports this interaction (PubMedID 28378844)
33

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PDLIM2	MKRN2
Description		PDZ and LIM domain 2	makorin ring finger protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Adherens Junction Z Disc Filamentous Actin	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Muscle Alpha-actinin Binding	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Heart Development Actin Cytoskeleton Organization Protein Catabolic Process Muscle Structure Development	Protein Polyubiquitination Negative Regulation Of Inflammatory Response To Antigenic Stimulus DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Parkinson's disease ( 28892059) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Survival in breast cancer (estrogen-receptor positive) ( 29423119)	Hip index ( 34021172) Monocyte percentage of white cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ACD APC AURKA BAG4 BCAR3 FGFR2 FGFR4 MKRN2 POT1 RAF1 TGFB1 UBC UBE2E2 ZNF695	14 interacting genes: AIRIM CLK1 EIF3F IGF2BP3 NDN PDLIM2 RACK1 RBCK1 RELA UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3
Entrez ID		64236	23609
HPRD ID		17831	09761
Ensembl ID		ENSG00000120913	ENSG00000075975
Uniprot IDs		Q96JY6	Q9H000
PDB IDs		2PA1 3PDV
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Activity Telomerase Inhibitor Activity Shelterin Complex Telomere Assembly Establishment Of Protein Localization To Telomere Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Insulin Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Branch Elongation Of An Epithelium Gland Development Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Fibroblast Migration Telomere Capping Ubiquitin Protein Ligase Binding Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Protein-containing Complex Binding Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Metabolic Process Protein Modification Process Fibroblast Growth Factor Binding Protein Phosphorylation Protein Autophosphorylation Positive Regulation Of Cell Cycle Axis Elongation Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Developmental Growth Involved In Morphogenesis Regulation Of Extracellular Matrix Disassembly RNA-templated DNA Biosynthetic Process Regulation Of Organelle Organization Phosphorylation	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein Metabolic Process Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Translation Regulator Activity Ubiquitin Protein Ligase Binding Regulation Of Protein Modification Process Translation Positive Regulation Of Protein Modification Process Protein Modification Process Transferase Activity Positive Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process NF-kappaB P50/p65 Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Protein Catabolic Process Nucleus Cytosol Positive Regulation Of NF-kappaB Transcription Factor Activity
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