PJA1 and NDNL2

Number of citations of the paper that reports this interaction (PMID 20864041)
40

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PJA1	NDNL2
Gene Name		praja ring finger 1, E3 ubiquitin protein ligase	necdin-like 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Chromosome, Telomeric Region Nucleus Cytoplasm Smc5-Smc6 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	DNA Repair DNA Recombination Positive Regulation Of Protein Ubiquitination Regulation Of Growth
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440	5 interactors: E2F1 EID3 NGFR PJA1 TRIM28
Entrez ID		64219	56160
HPRD ID		02335	10503
Ensembl ID		ENSG00000181191	ENSG00000185115
Uniprot IDs		Q8NG27	Q96MG7
PDB IDs		2L0B	3NW0
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway	Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Negative Regulation Of DNA Demethylation Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Hair Follicle Development Positive Regulation Of Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Convergent Extension Involved In Axis Elongation Positive Regulation Of Intracellular Transport Organ Development Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Anoikis Apoptotic Signaling Pathway Positive Regulation Of Odontogenesis Cellular Response To Stress Convergent Extension Negative Regulation Of Viral Release From Host Cell Regulation Of Intracellular Transport Regulation Of Odontogenesis Of Dentin-containing Tooth Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development System Development Regulation Of Glucose Import In Response To Insulin Stimulus Morphogenesis Of An Epithelium Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Hair Cycle Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Sumoylation MRNA Stabilization Embryonic Placenta Morphogenesis Protein Ubiquitination Positive Regulation Of Apoptotic Process Detection Of Temperature Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death DNA Repair Regulation Of Odontogenesis Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Multicellular Organismal Development Tissue Morphogenesis Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Axis Elongation Hair Follicle Morphogenesis
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