CARD9 and CCHCR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CARD9	CCHCR1
Description		caspase recruitment domain family member 9	coiled-coil alpha-helical rod protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CBM Complex Protein-containing Complex	Nucleus Cytoplasm Centriole Cytosol
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding CARD Domain Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Neutrophil Mediated Immunity JNK Cascade Response To Xenobiotic Stimulus Response To Fungus Positive Regulation Of Macromolecule Metabolic Process Immunoglobulin Mediated Immune Response Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Stress-activated MAPK Cascade Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Aldosterone Positive Regulation Of T-helper 17 Type Immune Response	Protein Export From Nucleus Cell Differentiation
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 21743469 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 22936669 28067908) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Takayasu arteritis ( 33308445) Ulcerative colitis ( 19915572 28067908 21297633 20228799)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Head and neck squamous cell carcinoma ( 32276964) Hematology traits ( 23263863) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Monocyte percentage of white cells ( 32888494) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Reticulocyte count ( 32888494) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)
Interacting Genes		139 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 CABP2 CARD10 CATSPERT CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CIMIP4 CSNK2A1 CWF19L2 DAXX DISC1 DRC4 DUSP13B DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 OTUD1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3	161 interacting genes: ABI1 ABI2 AIRIM ALAS1 AMOTL2 ANKRD11 ATG5 BFSP1 BICD2 BLOC1S2 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC13 CCDC136 CCDC197 CCDC33 CCDC88B CCNC CDC37 CDR2 CDR2L CDSN CEP55 CEP57 CEP63 CFAP53 CIMIP4 CNN1 CNOT2 CRACR2A CTAG1A CTAG1B DEUP1 DISC1 DMAP1 DRC4 DTNB DYDC1 EFHC2 EXOC4 EXOC7 EXOC8 FSD2 GLRX3 GNG13 GOLGA2 GOLGA6L9 GRAP2 HAUS1 HAUS8 HDDC3 HGFAC HOMEZ HOOK2 HSF2BP HSPB1 IFT20 IKBKG IKZF3 ING5 KIAA0753 KIFC3 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT75 LENG1 LHX8 LZTS1 MAD1L1 MBD3 MCRS1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NFKBID NINL NME7 NTAQ1 NUP54 NUP62 NUTM1 OIP5 PCM1 PFDN6 PIAS2 PIBF1 PKP2 PLEKHA7 POLD2 POLR2C POU6F2 PPP1R13B PRDM6 PRKCG PROSER3 RABGEF1 RALBP1 RBM17 RBM41 RCOR3 RINT1 RUSC1 SAMD11 SAT1 SMARCE1 SORBS3 SPAG5 SPG21 SSX2IP STAR STARD4 STMN2 STX11 SYCE1 SYCE1L TACC3 TADA2A TEKT1 TEX9 TFIP11 TPM1 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TRIM54 TRIML2 TSG101 TSGA10 TSHZ3 TXLNA TXLNB USHBP1 VPS52 VPS9D1 WASHC3 ZBTB16 ZFYVE19 ZGPAT ZNF620 ZNF629 ZNF655 ZNF774 ZRANB1 ZWINT
Entrez ID		64170	54535
HPRD ID		06236	05607
Ensembl ID		ENSG00000187796	ENSG00000204536
Uniprot IDs		Q9H257	A0A1U9X7G6 B0S7V6 B4DIA2 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P 9AVM 9AVN
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Keratin Filament Cytoskeleton Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Intermediate Filament Organization Organelle Organization Identical Protein Binding Centrosome Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoskeleton Organization Nucleus Cytoplasmic Microtubule Organization Supramolecular Fiber Organization A2A Adenosine Receptor Binding Regulation Of Metabolic Process Microtubule Binding PML Body Negative Regulation Of Viral Transcription Wnt Signaling Pathway Post-translational Protein Modification Regulation Of Viral Transcription Small Protein Activating Enzyme Binding CBM Complex Cilium Organization	Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Microtubule-based Process Centrosome Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Organelle Organization Structural Constituent Of Skin Epidermis Centriolar Satellite Keratin Filament Intermediate Filament Structural Molecule Activity Cytoplasm Spindle Pole Cytoskeleton-dependent Intracellular Transport Organelle Localization Microtubule Organizing Center Organization Microtubule Microtubule-based Transport Microtubule Cytoskeleton Organization Cytosol Flemming Body Transport Along Microtubule Microtubule-based Movement Organelle Assembly Protein Localization To Centrosome Identical Protein Binding Microtubule Binding Centrosome Cycle Protein Localization To Cytoskeleton Signaling Adaptor Activity Establishment Of Localization In Cell Intracellular Transport Cell Division Centriole Regulation Of Microtubule Cytoskeleton Organization Epithelial Cell Differentiation Cellular Localization Microtubule Organizing Center Cilium Assembly Ciliary Basal Body Structural Constituent Of Cytoskeleton Establishment Of Organelle Localization Vesicle Tethering Involved In Exocytosis Axonemal A Tubule Inner Sheath Thioesterase Binding Syntaxin Binding
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