CARD9 and KRT75

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CARD9	KRT75
Description		caspase recruitment domain family member 9	keratin 75
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CBM Complex Protein-containing Complex	Cornified Envelope Cytosol Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding CARD Domain Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Neutrophil Mediated Immunity JNK Cascade Response To Xenobiotic Stimulus Response To Fungus Positive Regulation Of Macromolecule Metabolic Process Immunoglobulin Mediated Immune Response Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Stress-activated MAPK Cascade Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Aldosterone Positive Regulation Of T-helper 17 Type Immune Response	Hematopoietic Progenitor Cell Differentiation Keratinization Intermediate Filament Organization
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling	Keratinization Formation of the cornified envelope
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)	Pseudofolliculitis barbae
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 21743469 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 22936669 28067908) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Takayasu arteritis ( 33308445) Ulcerative colitis ( 19915572 28067908 21297633 20228799)
Interacting Genes		139 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 CABP2 CARD10 CATSPERT CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CIMIP4 CSNK2A1 CWF19L2 DAXX DISC1 DRC4 DUSP13B DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 OTUD1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3	119 interacting genes: - ABI2 AIRIM AMOT ANKS1A ARMC7 ASB15 BCAS2 BEX2 C19orf25 C1orf216 CAMK2A CARD10 CARD9 CATSPERT CCDC102B CCDC197 CCHCR1 CDC37 CDK18 CDKN2D CEP57 CFAP206 CPNE7 CRACR2A DHX15 DMAP1 DTNBP1 DYDC1 EFHC1 EPM2AIP1 FBXO17 FKBP6 GLYCTK GMCL1 GOLGA2 GOLGA6L9 GPANK1 HGS HNRNPF INCA1 IQUB KANK2 KCTD7 KIF9 KIFC3 KRT13 KRT20 KRT24 KRT25 KRT26 KRT27 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 KRT76 LCA5L LMO1 LMO2 LMO4 LONRF1 MAGOHB MID2 MKRN3 MNS1 MTUS2 MYO15B MYOZ3 NCDN NDC80 NEK6 NFKBID NME7 NUDT21 NUP62 OIP5 OSGIN1 PLEKHG4 PM20D2 POLR1C POLR3C RCOR3 RSPH14 SCNM1 SMARCD1 SPAG5 SPTA1 STX11 SUFU TBC1D1 TCHP TEKT1 TEKT4 TJAP1 TNPO2 TNPO3 TRAF1 TRIM23 TRIM27 TRIM54 TRIML2 TSG101 TSSK3 TXLNA TXLNB U2AF1 USHBP1 WASHC1 WASHC3 WWOX XPOT ZNF76 ZWINT
Entrez ID		64170	9119
HPRD ID		06236	11057
Ensembl ID		ENSG00000187796	ENSG00000170454
Uniprot IDs		Q9H257	O95678
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P 9AVM 9AVN
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Keratin Filament Cytoskeleton Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Intermediate Filament Organization Organelle Organization Identical Protein Binding Centrosome Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoskeleton Organization Nucleus Cytoplasmic Microtubule Organization Supramolecular Fiber Organization A2A Adenosine Receptor Binding Regulation Of Metabolic Process Microtubule Binding PML Body Negative Regulation Of Viral Transcription Wnt Signaling Pathway Post-translational Protein Modification Regulation Of Viral Transcription Small Protein Activating Enzyme Binding CBM Complex Cilium Organization	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Protein Binding Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Motile Cilium Organelle Organization Axonemal A Tubule Inner Sheath Radial Spoke Microtubule-based Process Sperm Flagellum Axonemal Microtubule Cytoplasm Microtubule-based Movement Flagellated Sperm Motility Sperm Motility Cytosol Cilium-dependent Cell Motility Cilium Movement Cilium Movement Involved In Cell Motility Cilium Identical Protein Binding Microtubule Binding Regulation Of Actin Nucleation Microtubule Regulation Of Organelle Organization Spliceosomal Complex CBM Complex Centrosome Regulation Of Arp2/3 Complex-mediated Actin Nucleation Phosphatidylinositol 3-kinase Inhibitor Activity Polymeric Cytoskeletal Fiber Spindle Organization
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