CARD9 and MCRS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CARD9	MCRS1
Description		caspase recruitment domain family member 9	microspherule protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CBM Complex Protein-containing Complex	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Lysosome Centrosome Cytoskeleton Nuclear Body Dendrite Ino80 Complex Centriolar Satellite Perikaryon NSL Complex MLL1 Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding CARD Domain Binding	G-quadruplex RNA Binding Protein Binding Poly(U) RNA Binding Telomerase Inhibitor Activity Poly(G) Binding
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Neutrophil Mediated Immunity JNK Cascade Response To Xenobiotic Stimulus Response To Fungus Positive Regulation Of Macromolecule Metabolic Process Immunoglobulin Mediated Immune Response Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Stress-activated MAPK Cascade Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Aldosterone Positive Regulation Of T-helper 17 Type Immune Response	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Protein Localization To Nucleolus
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 21743469 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 22936669 28067908) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Takayasu arteritis ( 33308445) Ulcerative colitis ( 19915572 28067908 21297633 20228799)
Interacting Genes		139 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 CABP2 CARD10 CATSPERT CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CIMIP4 CSNK2A1 CWF19L2 DAXX DISC1 DRC4 DUSP13B DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 OTUD1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3	125 interacting genes: AGGF1 ARK2N AXIN2 BACH2 BEND3 BHLHA9 BHLHE40 BLM BRD8 BRMS1 BRMS1L C7orf57 C8orf34 CARD9 CATSPERT CAVIN2 CBY2 CCDC13 CCDC136 CCDC85B CCHCR1 CCNH CDCA7L CEP44 CEP70 CNTROB COIL CREB3L3 CRYAA CYSRT1 CYTIP DAXX DRAP1 DSCR9 DVL2 EGR2 ERF EVI5 FAM9A FNDC8 FSD2 FXR1 FXR2 GAS7 GCC1 GEM GIGYF1 GOLGA2 GPBP1 HMBOX1 HOOK2 IKZF1 IKZF3 IKZF4 JAKMIP1 KANK2 KAT7 KDM1A KIAA1958 KRT35 KRTAP10-7 KRTAP2-3 KRTAP2-4 KXD1 LIG4 LSM6 LZTS1 MAGEA11 MAGEA6 MAPK9 MED4 MEOX1 MFAP1 MIER2 MIER3 NAA10 NAB2 NKAPD1 NOP2 OSBPL3 PBK PBX2 PCM1 PHC2 PIBF1 PINX1 PKNOX2 PPP1R13B PRMT5 PSTPIP1 PTEN RABEP1 RALYL RARA RETREG3 RIPPLY3 SH2B2 SHANK3 SNAPC5 SP4 SRRM4 SSMEM1 SUV39H1 TADA2B TBC1D1 TERT TFAP4 TLE5 TNIP1 TNNI1 TP63 TRIM37 TRIM41 TSPYL2 UPF3B USHBP1 WASHC3 WBP11 XIAP ZBTB22 ZCCHC12 ZNF23 ZNF639 ZNF8 ZRANB1
Entrez ID		64170	10445
HPRD ID		06236	11298
Ensembl ID		ENSG00000187796	ENSG00000187778
Uniprot IDs		Q9H257	Q96EZ8
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P 9AVM 9AVN
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Keratin Filament Cytoskeleton Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Intermediate Filament Organization Organelle Organization Identical Protein Binding Centrosome Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoskeleton Organization Nucleus Cytoplasmic Microtubule Organization Supramolecular Fiber Organization A2A Adenosine Receptor Binding Regulation Of Metabolic Process Microtubule Binding PML Body Negative Regulation Of Viral Transcription Wnt Signaling Pathway Post-translational Protein Modification Regulation Of Viral Transcription Small Protein Activating Enzyme Binding CBM Complex Cilium Organization	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone Deacetylase Binding Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Protein-containing Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleolus Chromatin Binding Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Protein Domain Specific Binding Chromatin Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Stem Cell Proliferation Regulation Of Nervous System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Senescence Regulation Of Centromeric Sister Chromatid Cohesion MRF Binding Telomere Maintenance Via Telomerase Sequence-specific DNA Binding
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