CARD9 and TNFAIP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CARD9	TNFAIP1
Gene Name		caspase recruitment domain family, member 9	tumor necrosis factor, alpha-induced protein 1 (endothelial)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleolus Cytoplasm Endosome Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Homodimerization Activity CARD Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding GTP-Rho Binding Protein Domain Specific Binding
	Biological Process	Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Drug Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	DNA Replication Apoptotic Process Immune Response Embryo Development Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization
Pathways		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Crohn's disease ( 22936669 21102463) Inflammatory bowel disease ( 23128233) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661) Ulcerative colitis ( 19915572 20228799 21297633)
Protein-Protein Interactions		65 interactors: ABLIM1 AES ALS2CR11 AMOTL2 BCL10 BLZF1 C1orf94 CCDC36 CCDC85B CCHCR1 CDCA7L CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DUSP13 EIF4E2 FAM124B FAM161A FAM208B FAM50B HMBOX1 IQCE KCTD9 KIAA0408 KIF9 KRT19 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 LENG1 LMO1 LZTS2 MEOX2 MFAP1 NECAB2 PAK7 PBX2 PHC2 PNMA5 PPP1R18 RTP5 SSX2IP STX11 SUMO1 TCEANC TCL1A TFIP11 TNFAIP1 TRIM23 TRIM29 TRIM42 TRIM54 TSNAX USP15 VPS28 ZCCHC7 ZNF250 ZNF417 ZNF572 ZNF587 ZNF655	21 interactors: ARMC7 ARNT CAPN7 CARD9 CSNK2B CUL3 EPHA2 EPM2AIP1 EXOSC5 HAT1 KCTD13 KDM1A POLR1C PSMA1 RHOA RHOB RIN3 STK16 SUV39H1 SVIL ZDHHC17
Entrez ID		64170	7126
HPRD ID		06236	01856
Ensembl ID		ENSG00000187796	ENSG00000109079
Uniprot IDs		Q9H257	Q13829
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Organelle Organization Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Developmental Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Wnt Signaling Pathway Spliceosomal Complex Disassembly Organelle Assembly Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Mast Cell Cytokine Production Histone H2B Conserved C-terminal Lysine Deubiquitination Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Negative Regulation Of Biosynthetic Process	Regulation Of Signal Transduction Regulation Of Signaling Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Cycle Process Positive Regulation Of Hormone Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Division Response To Stress Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cellular Process Regulation Of Hormone Biosynthetic Process Regulation Of Epithelial Cell Migration Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Intracellular Signal Transduction Chromatin Silencing Regulation Of Hormone Metabolic Process Locomotion Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Erythrocyte Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To External Stimulus Cell Cycle Regulation Of Cell Cycle Process Regulation Of Gene Expression, Epigenetic Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Axonogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Primitive Erythrocyte Differentiation Notochord Cell Development Viral Process Movement Of Cell Or Subcellular Component Axon Development Rho Protein Signal Transduction Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Cell Division
Tagcloud ?		adapter assembly danger defense discuss engaged framework fungal homeostasis inducible innate lectin links lymphoid lymphoma malt mucosa multifunctional nonredundant oligomerization paracaspase polymorphisms responds rig rlrs sensors spleen syk	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Difference) ?		adapter assembly danger defense discuss engaged framework fungal homeostasis innate lectin links lymphoid lymphoma malt mucosa multifunctional nonredundant oligomerization paracaspase polymorphisms responds rig rlrs sensors spleen syk	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Intersection) ?		inducible