CARD9 and VCPKMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CARD9	VCPKMT
Description		caspase recruitment domain family member 9	valosin containing protein lysine methyltransferase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CBM Complex Protein-containing Complex	Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding CARD Domain Binding	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity ATPase Binding
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Neutrophil Mediated Immunity JNK Cascade Response To Xenobiotic Stimulus Response To Fungus Positive Regulation Of Macromolecule Metabolic Process Immunoglobulin Mediated Immune Response Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Stress-activated MAPK Cascade Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Aldosterone Positive Regulation Of T-helper 17 Type Immune Response	Peptidyl-lysine Methylation Peptidyl-lysine Trimethylation Methylation Negative Regulation Of ATP-dependent Activity
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling	Protein methylation
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 21743469 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 22936669 28067908) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Takayasu arteritis ( 33308445) Ulcerative colitis ( 19915572 28067908 21297633 20228799)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874)
Interacting Genes		139 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 CABP2 CARD10 CATSPERT CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CIMIP4 CSNK2A1 CWF19L2 DAXX DISC1 DRC4 DUSP13B DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 OTUD1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3	3 interacting genes: ASPSCR1 CARD9 VCP
Entrez ID		64170	79609
HPRD ID		06236	16605
Ensembl ID		ENSG00000187796	ENSG00000100483
Uniprot IDs		Q9H257	Q9H867
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P 9AVM 9AVN	4LG1 7OAT 8HL6 8HL7
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Keratin Filament Cytoskeleton Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Intermediate Filament Organization Organelle Organization Identical Protein Binding Centrosome Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoskeleton Organization Nucleus Cytoplasmic Microtubule Organization Supramolecular Fiber Organization A2A Adenosine Receptor Binding Regulation Of Metabolic Process Microtubule Binding PML Body Negative Regulation Of Viral Transcription Wnt Signaling Pathway Post-translational Protein Modification Regulation Of Viral Transcription Small Protein Activating Enzyme Binding CBM Complex Cilium Organization	Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Positive Regulation Of Protein Metabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Cytoplasm Protein Quality Control Regulation Of Protein Metabolic Process BAT3 Complex Binding Positive Regulation Of Protein Deubiquitination CBM Complex Protein-DNA Covalent Cross-linking Repair Stress Granule Disassembly Positive Regulation Of Mitochondrial Membrane Potential Inclusion Body Assembly Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Derlin-1 Retrotranslocation Complex Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway VCP-NPL4-UFD1 AAA ATPase Complex Positive Regulation Of Protein Modification Process Regulation Of Protein Localization To Chromatin Deubiquitinase Activator Activity Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Protein Deubiquitination Positive Regulation Of Membrane Potential K48-linked Polyubiquitin Modification-dependent Protein Binding ATPase Complex Ubiquitin-modified Protein Reader Activity Cellular Response To Misfolded Protein Positive Regulation Of Cellular Respiration Response To Misfolded Protein Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Antifungal Innate Immune Response Response To Peptidoglycan CARD Domain Binding Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Retrograde Protein Transport, ER To Cytosol Intracellular Protein Transport Cellular Response To Arsenic-containing Substance Response To Aldosterone MHC Class I Protein Binding Regulation Of ATP Biosynthetic Process Ubiquitin-specific Protease Binding Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of T-helper 17 Type Immune Response Viral Genome Replication
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