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CCHCR1 and POLD2
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CCHCR1
POLD2
Gene Name
coiled-coil alpha-helical rod protein 1
polymerase (DNA directed), delta 2, accessory subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Centriole
Nucleus
Nucleoplasm
Molecular Function
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Biological Process
Protein Export From Nucleus
Multicellular Organismal Development
Cell Differentiation
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Leading Strand Synthesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Polymerase switching
Telomere Maintenance
Removal of DNA patch containing abasic residue
Resolution of Abasic Sites (AP sites)
Removal of the Flap Intermediate from the C-strand
Base Excision Repair
Polymerase switching on the C-strand of the telomere
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Hematology traits (
23263863
)
Nevirapine-induced rash (
21810746
)
Prostate cancer (
21743467
)
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) (
21912425
)
White blood cell count (
21738480
)
Protein-Protein Interactions
57 interactors:
ABI2
ALAS1
AMOTL2
ATG5
BLOC1S6
C1orf94
CARD9
CCDC102B
CCDC136
CCDC53
CDR2
CEP55
CTAGE5
DTNBP1
EFHC2
FSD2
GOLGA2
HAUS1
HSBP1
IKBKG
KRT13
KRT15
KRT31
KRT40
MAD1L1
MED4
MID2
MTUS2
NAB2
NDC80
NDEL1
NINL
NME7
NUP62
NUTM1
PIAS2
POLD2
POLR2C
PRKCG
RBM17
SAT1
SPAG5
SSX2IP
STAR
TADA2A
TEKT1
TFIP11
TPM3
TRAF1
TRAF2
TRAF4
TRIM27
TSGA10
TXLNA
TXLNB
USHBP1
ZFYVE19
16 interactors:
CCHCR1
CDK2
CDKN1A
EP300
KCTD13
LSM6
PCNA
POLD1
POLD3
POLD4
POLDIP2
POLDIP3
SOX12
WRN
WRNIP1
XRN1
Entrez ID
54535
5425
HPRD ID
05607
15982
Ensembl ID
ENSG00000204536
ENSG00000106628
Uniprot IDs
B0S7V6
D2IYK9
M1T2K8
M1TIV4
Q2TB68
Q769H0
Q8TD31
A4D2J4
B2R5S4
P49005
PDB IDs
3E0J
Enriched GO Terms of Interacting Partners
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Mitotic Cell Cycle
Mitotic Cell Cycle Process
Microtubule-based Transport
Activation Of NF-kappaB-inducing Kinase Activity
Cytoskeleton-dependent Intracellular Transport
Organelle Organization
Positive Regulation Of NIK/NF-kappaB Signaling
Cell Cycle Process
NIK/NF-kappaB Signaling
Mitotic Nuclear Division
Cell Cycle
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Microtubule-based Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Axon Cargo Transport
Innate Immune Response
Cell Division
Positive Regulation Of Protein Homodimerization Activity
Cytoskeleton Organization
Microtubule-based Movement
Establishment Of Organelle Localization
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Transcription
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Viral Release From Host Cell
Establishment Of Vesicle Localization
Intracellular Receptor Signaling Pathway
Anterograde Synaptic Vesicle Transport
Negative Regulation Of Neuron Death
Vesicle Localization
Regulation Of Protein Homodimerization Activity
Centrosome Organization
Negative Regulation Of Viral Transcription
Melanosome Organization
Establishment Of Localization In Cell
Pigment Granule Organization
Regulation Of Viral Release From Host Cell
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Developmental Process
Organelle Localization
Microtubule Organizing Center Organization
Cellular Localization
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Anterograde Axon Cargo Transport
Regulation Of Apoptotic Process
Microtubule Cytoskeleton Organization
Positive Regulation Of JNK Cascade
Spindle Organization
Regulation Of Cell Death
DNA Replication
DNA Biosynthetic Process
DNA Synthesis Involved In DNA Repair
Nucleotide-excision Repair, DNA Gap Filling
Base-excision Repair
Telomere Maintenance Via Semi-conservative Replication
Cellular Response To DNA Damage Stimulus
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Telomere Maintenance
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
DNA-dependent DNA Replication
Transcription-coupled Nucleotide-excision Repair
DNA Repair
Mismatch Repair
Chromosome Organization
Cellular Response To Stress
DNA Metabolic Process
Mitotic Cell Cycle
DNA Recombination
Nucleotide-excision Repair
Regulation Of DNA Replication
Nucleobase-containing Compound Metabolic Process
Cell Cycle Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Organelle Organization
Regulation Of DNA-dependent DNA Replication Initiation
Cell Cycle
Response To Stress
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Macromolecule Biosynthetic Process
Signal Transduction By P53 Class Mediator
G2/M Transition Of Mitotic Cell Cycle
Response To UV
Positive Regulation Of DNA Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Mitochondrion Morphogenesis
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
G1/S Transition Of Mitotic Cell Cycle
Cellular Macromolecule Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Biosynthetic Process
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