CCHCR1 and TRAF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CCHCR1	TRAF2
Description		coiled-coil alpha-helical rod protein 1	TNF receptor associated factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centriole Cytosol	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane Protein-containing Complex CD40 Receptor Complex Receptor Complex Membrane Raft TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Protein Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Lipid Binding Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein-macromolecule Adaptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Export From Nucleus Cell Differentiation	Regulation Of Immunoglobulin Production Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of T Cell Cytokine Production Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Ubiquitination Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction TORC1 Signaling TORC2 Signaling T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Innate Immune Response Regulation Of JNK Cascade MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Interleukin-17-mediated Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway TORC1 Complex Assembly TORC2 Complex Disassembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Head and neck squamous cell carcinoma ( 32276964) Hematology traits ( 23263863) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Monocyte percentage of white cells ( 32888494) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Reticulocyte count ( 32888494) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)	Platelet distribution width ( 32888494)
Interacting Genes		161 interacting genes: ABI1 ABI2 AIRIM ALAS1 AMOTL2 ANKRD11 ATG5 BFSP1 BICD2 BLOC1S2 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC13 CCDC136 CCDC197 CCDC33 CCDC88B CCNC CDC37 CDR2 CDR2L CDSN CEP55 CEP57 CEP63 CFAP53 CIMIP4 CNN1 CNOT2 CRACR2A CTAG1A CTAG1B DEUP1 DISC1 DMAP1 DRC4 DTNB DYDC1 EFHC2 EXOC4 EXOC7 EXOC8 FSD2 GLRX3 GNG13 GOLGA2 GOLGA6L9 GRAP2 HAUS1 HAUS8 HDDC3 HGFAC HOMEZ HOOK2 HSF2BP HSPB1 IFT20 IKBKG IKZF3 ING5 KIAA0753 KIFC3 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT75 LENG1 LHX8 LZTS1 MAD1L1 MBD3 MCRS1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NFKBID NINL NME7 NTAQ1 NUP54 NUP62 NUTM1 OIP5 PCM1 PFDN6 PIAS2 PIBF1 PKP2 PLEKHA7 POLD2 POLR2C POU6F2 PPP1R13B PRDM6 PRKCG PROSER3 RABGEF1 RALBP1 RBM17 RBM41 RCOR3 RINT1 RUSC1 SAMD11 SAT1 SMARCE1 SORBS3 SPAG5 SPG21 SSX2IP STAR STARD4 STMN2 STX11 SYCE1 SYCE1L TACC3 TADA2A TEKT1 TEX9 TFIP11 TPM1 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TRIM54 TRIML2 TSG101 TSGA10 TSHZ3 TXLNA TXLNB USHBP1 VPS52 VPS9D1 WASHC3 ZBTB16 ZFYVE19 ZGPAT ZNF620 ZNF629 ZNF655 ZNF774 ZRANB1 ZWINT	380 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AGR2 AIMP2 AKR1B15 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARHGEF6 ARNT2 ARSJ ASCC1 ATOSB ATXN1 ATXN7 AXIN1 BAHD1 BANP BAZ2B BCL10 BCL6 BEX2 BEX3 BIRC2 BIRC3 BOD1L2 BYSL C22orf15 CALCOCO2 CAPN15 CASP8 CASP8AP2 CATSPER1 CATSPERT CAV1 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC37 CDC42 CDCA3 CDK18 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHCHD2 CHMP2B CHUK CREB5 CRY1 CRY2 CRYBA2 CTCF CWF19L2 CYB5R2 CYLD DDI1 DDX6 DGCR6 DLGAP5 DMTN DRC4 DTNB DVL2 DVL3 DYRK1A EAF1 EBF2 EDAR EDARADD EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 EP400 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM124B FAM161A FAM161B FAM50B FAM90A1 FAM9A FARS2 FATE1 FBF1 FBXO28 FDXACB1 FLNA FLYWCH1 FNDC11 FNDC3B FOXN1 FXR1 FXR2 GABPB1 GCA GCKR GEM GORASP2 GPANK1 GPKOW GRIPAP1 GSE1 GSG1 GSTP1 GSTZ1 HENMT1 HINFP HIVEP3 HOXA1 HOXB5 HSPA12B IKBKB IL15RA IMPDH2 INO80B IP6K3 IPO11 IQUB IRF4 ITPK1 ITPRIPL1 JUN KANK2 KANSL1 KIAA0408 KIAA1217 KIF26B KIFC3 KLF3 LENG1 LINC02875 LNX1 LNX2 LONRF1 LRRK2 LTBR LYSMD1 LZTS2 MACROH2A1 MALT1 MAP3K1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MBLAC1 METTL13 MFAP1 MISP MKRN3 MORN3 MOS MPP3 MSRB2 MVP MYO15B NAB2 NATD1 NCAPH2 NEBL NECAP2 NEDD9 NEK6 NFIL3 NFKBID NGFR NHSL2 NIF3L1 NMUR2 NOXA1 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PALS1 PCGF2 PCGF5 PDLIM7 PDZD4 PEG3 PGBD1 PIAS2 PIBF1 PIN1 PKN1 POLR3C POM121 PPL PPP1R18 PRKAB2 PRKRIP1 PRPF18 PSMB1 PSMD9 PSME3IP1 PSMF1 QARS1 QRICH1 RAD23A RAD54L2 RALBP1 RANBP3 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIN1 RIPK1 RIPK2 RIPK3 RIPPLY1 RIPPLY3 RNF146 RNF4 RRAS2 RSPH14 SAMD11 SAXO4 SCNM1 SETD5 SH2D4A SHC3 SIAH2 SMG9 SMURF2 SNAI1 SNRNP25 SOX13 SOX30 SOX5 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCAF1 TCEA2 TCEANC TCL1A TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TIGD4 TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM14 TRIM31 TRIM37 TRIM42 TRIM50 TROAP TRPC4AP TRPT1 TSGA10IP TSHZ2 TSHZ3 TSSC4 TTC23 TXN UBC UBE2D1 UBE2D2 UBE2I UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 UTP14C UTP23 VEZF1 VWA2 WASF1 YES1 YJU2B ZBTB16 ZBTB24 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZKSCAN3 ZMAT2 ZMYM5 ZNF205 ZNF250 ZNF35 ZNF410 ZNF417 ZNF438 ZNF488 ZNF544 ZNF572 ZNF574 ZNF646 ZNF648 ZNF655 ZNF662 ZNF688 ZNF774 ZSCAN23 ZSCAN32 ZSWIM3 ZZZ3
Entrez ID		54535	7186
HPRD ID		05607	03538
Ensembl ID		ENSG00000204536	ENSG00000127191
Uniprot IDs		A0A1U9X7G6 B0S7V6 B4DIA2 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31	Q12933
PDB IDs			1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D 8T5Q
Enriched GO Terms of Interacting Partners?		Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Microtubule-based Process Centrosome Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Organelle Organization Structural Constituent Of Skin Epidermis Centriolar Satellite Keratin Filament Intermediate Filament Structural Molecule Activity Cytoplasm Spindle Pole Cytoskeleton-dependent Intracellular Transport Organelle Localization Microtubule Organizing Center Organization Microtubule Microtubule-based Transport Microtubule Cytoskeleton Organization Cytosol Flemming Body Transport Along Microtubule Microtubule-based Movement Organelle Assembly Protein Localization To Centrosome Identical Protein Binding Microtubule Binding Centrosome Cycle Protein Localization To Cytoskeleton Signaling Adaptor Activity Establishment Of Localization In Cell Intracellular Transport Cell Division Centriole Regulation Of Microtubule Cytoskeleton Organization Epithelial Cell Differentiation Cellular Localization Microtubule Organizing Center Cilium Assembly Ciliary Basal Body Structural Constituent Of Cytoskeleton Establishment Of Organelle Localization Vesicle Tethering Involved In Exocytosis Axonemal A Tubule Inner Sheath Thioesterase Binding Syntaxin Binding	Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Programmed Cell Death Cell Death Positive Regulation Of Post-translational Protein Modification Tumor Necrosis Factor Receptor Activity Positive Regulation Of Protein Modification Process Apoptotic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Identical Protein Binding Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process MAPK Cascade Positive Regulation Of Protein Metabolic Process CD40 Receptor Complex Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process
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