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CCHCR1 and TRAF2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
CCHCR1
TRAF2
Gene Name
coiled-coil alpha-helical rod protein 1
TNF receptor-associated factor 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Centriole
Ubiquitin Ligase Complex
Cytoplasm
Cytosol
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Vesicle Membrane
CD40 Receptor Complex
Membrane Raft
TRAF2-GSTP1 Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Tumor Necrosis Factor Receptor Binding
CD40 Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Enzyme Binding
Protein Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Protein Complex Binding
Identical Protein Binding
Sphingolipid Binding
Biological Process
Protein Export From Nucleus
Multicellular Organismal Development
Cell Differentiation
Positive Regulation Of T Cell Cytokine Production
Protein Complex Assembly
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Protein Catabolic Process
Positive Regulation Of Interleukin-2 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Cellular Protein Complex Assembly
Innate Immune Response
Positive Regulation Of T Cell Activation
Regulation Of Immunoglobulin Secretion
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Heterooligomerization
Protein Autoubiquitination
Protein Homotrimerization
Protein K63-linked Ubiquitination
Cellular Response To Nitric Oxide
Positive Regulation Of Protein Homodimerization Activity
Programmed Necrotic Cell Death
Negative Regulation Of Neuron Death
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Regulation by c-FLIP
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Dimerization of procaspase-8
Caspase-8 activation by cleavage
Programmed Cell Death
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
Innate Immune System
Drugs
Diseases
GWAS
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Hematology traits (
23263863
)
Nevirapine-induced rash (
21810746
)
Prostate cancer (
21743467
)
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) (
21912425
)
White blood cell count (
21738480
)
Protein-Protein Interactions
57 interactors:
ABI2
ALAS1
AMOTL2
ATG5
BLOC1S6
C1orf94
CARD9
CCDC102B
CCDC136
CCDC53
CDR2
CEP55
CTAGE5
DTNBP1
EFHC2
FSD2
GOLGA2
HAUS1
HSBP1
IKBKG
KRT13
KRT15
KRT31
KRT40
MAD1L1
MED4
MID2
MTUS2
NAB2
NDC80
NDEL1
NINL
NME7
NUP62
NUTM1
PIAS2
POLD2
POLR2C
PRKCG
RBM17
SAT1
SPAG5
SSX2IP
STAR
TADA2A
TEKT1
TFIP11
TPM3
TRAF1
TRAF2
TRAF4
TRIM27
TSGA10
TXLNA
TXLNB
USHBP1
ZFYVE19
247 interactors:
AASDHPPT
ABLIM1
ACTN3
AES
AFF4
AIMP2
ALPL
AMOTL2
ANKRD11
ANKRD36BP1
APEX2
APPL1
AQP1
ARNT2
ARSJ
ASCC1
ATXN1
ATXN7
BAHD1
BANP
BCL10
BEX2
BIRC2
BIRC3
C14orf105
C17orf82
CALCOCO2
CASP8
CASP8AP2
CATSPER1
CAV1
CBX8
CCDC130
CCDC33
CCHCR1
CCNJL
CD27
CD40
CDC20B
CDC42
CDCA3
CDK9
CDKN1B
CEP57L1
CFAP57
CFLAR
CHMP2B
CHUK
CREB5
CRY1
CYB5R2
CYLD
DGCR6
DLGAP5
DTNB
DVL2
EDAR
EDARADD
EFEMP1
EIF4G1
ENKD1
EP300
ERN1
EWSR1
EXOC3-AS1
FADD
FAM107A
FAM120B
FAM192A
FAM90A1
FATE1
FBF1
FBXO28
FDXACB1
FLNA
FNDC3B
FXR2
GABPB1
GCKR
GORASP2
GPKOW
GSG1
GSTP1
HENMT1
HINFP
HIVEP3
IKBKB
IKBKE
IKBKG
IL15RA
IPO11
IQUB
IRF4
ITPK1
JUN
KANSL1
KIAA0408
KIF26B
KIFC3
KLF3
LNX1
LRRK2
LTBR
LZTS2
MALT1
MAP3K14
MAP3K5
MAP3K8
MAP4K2
MAP4K5
MAPK9
MAPRE1
MAST2
MORN3
MPP3
MVP
NATD1
NEBL
NECAP2
NFIL3
NGFR
NGFRAP1
NIF3L1
NMUR2
NR2C2
NRF1
NRIP1
NUDT16L1
NUDT18
PACS2
PCGF5
PDLIM7
PEG3
PGBD1
PIN1
PKN1
PPL
PPP1R18
PRKAB2
PRKRIP1
PSMF1
QARS
RAD23A
RALBP1
RAPGEF4
RASSF5
RBM41
RCOR3
RFX3
RGS14
RIBC2
RIPK1
RIPK2
RIPK3
RIPPLY1
RNF146
RRAS2
SETD5
SH2D4A
SIAH2
SMG9
SMURF2
SNRNP25
SOX30
SOX9
SPATA2
SPG21
SPHK1
SPRY2
SUMO1P1
SYT17
TAB1
TAB2
TAB3
TANK
TAOK3
TBK1
TCEA2
TCEANC
TCEB3B
TDP2
TEKT3
THAP7
THOP1
TICAM1
TIFA
TNF
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF25
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF4
TNFSF9
TNIK
TRADD
TRAF1
TRAF3
TRAF3IP2
TRAF5
TRAF6
TRAIP
TRIM31
TRIM37
TRIM42
TROAP
TRPC4AP
TRPT1
TSHZ3
TSSC4
UBE2D1
UBE2N
UBE2V1
UBE2V2
UBQLN4
UBXN11
USF1
USP2
USP4
USP53
USP7
VWA2
YES1
ZBTB16
ZBTB25
ZBTB43
ZBTB49
ZC2HC1C
ZFAND6
ZMAT2
ZNF205
ZNF410
ZNF488
ZNF544
ZNF646
ZNF655
ZNF662
ZSCAN32
Entrez ID
54535
7186
HPRD ID
05607
03538
Ensembl ID
ENSG00000204536
ENSG00000127191
Uniprot IDs
B0S7V6
D2IYK9
M1T2K8
M1TIV4
Q2TB68
Q769H0
Q8TD31
Q12933
PDB IDs
1CA4
1CA9
1CZY
1CZZ
1D00
1D01
1D0A
1D0J
1F3V
1QSC
3KNV
3M06
3M0A
3M0D
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Microtubule-based Transport
Activation Of NF-kappaB-inducing Kinase Activity
Cytoskeleton-dependent Intracellular Transport
Organelle Organization
Positive Regulation Of NIK/NF-kappaB Signaling
Cell Cycle Process
NIK/NF-kappaB Signaling
Mitotic Nuclear Division
Cell Cycle
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Microtubule-based Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Axon Cargo Transport
Innate Immune Response
Cell Division
Positive Regulation Of Protein Homodimerization Activity
Cytoskeleton Organization
Microtubule-based Movement
Establishment Of Organelle Localization
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Transcription
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Viral Release From Host Cell
Establishment Of Vesicle Localization
Intracellular Receptor Signaling Pathway
Anterograde Synaptic Vesicle Transport
Negative Regulation Of Neuron Death
Vesicle Localization
Regulation Of Protein Homodimerization Activity
Centrosome Organization
Negative Regulation Of Viral Transcription
Melanosome Organization
Establishment Of Localization In Cell
Pigment Granule Organization
Regulation Of Viral Release From Host Cell
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Developmental Process
Organelle Localization
Microtubule Organizing Center Organization
Cellular Localization
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Anterograde Axon Cargo Transport
Regulation Of Apoptotic Process
Microtubule Cytoskeleton Organization
Positive Regulation Of JNK Cascade
Spindle Organization
Regulation Of Cell Death
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Metabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Programmed Cell Death
Death
Toll-like Receptor 4 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Innate Immune Response-activating Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor Signaling Pathway
Activation Of Innate Immune Response
Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
Signal Transduction
Cellular Response To Stimulus
Cell Communication
Regulation Of Apoptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Signaling
Regulation Of Phosphorylation
Immune Response-regulating Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cell Death
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Immune Response
Intracellular Signal Transduction
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf3
traf5
traf6
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf3
traf5
traf6
transduction
Tagcloud (Intersection)
?