CCHCR1 and MBD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCHCR1	MBD3
Description		coiled-coil alpha-helical rod protein 1	methyl-CpG binding domain protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centriole Cytosol	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Protein Export From Nucleus Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Head and neck squamous cell carcinoma ( 32276964) Hematology traits ( 23263863) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Monocyte percentage of white cells ( 32888494) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Reticulocyte count ( 32888494) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)
Interacting Genes		161 interacting genes: ABI1 ABI2 AIRIM ALAS1 AMOTL2 ANKRD11 ATG5 BFSP1 BICD2 BLOC1S2 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC13 CCDC136 CCDC197 CCDC33 CCDC88B CCNC CDC37 CDR2 CDR2L CDSN CEP55 CEP57 CEP63 CFAP53 CIMIP4 CNN1 CNOT2 CRACR2A CTAG1A CTAG1B DEUP1 DISC1 DMAP1 DRC4 DTNB DYDC1 EFHC2 EXOC4 EXOC7 EXOC8 FSD2 GLRX3 GNG13 GOLGA2 GOLGA6L9 GRAP2 HAUS1 HAUS8 HDDC3 HGFAC HOMEZ HOOK2 HSF2BP HSPB1 IFT20 IKBKG IKZF3 ING5 KIAA0753 KIFC3 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT75 LENG1 LHX8 LZTS1 MAD1L1 MBD3 MCRS1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NFKBID NINL NME7 NTAQ1 NUP54 NUP62 NUTM1 OIP5 PCM1 PFDN6 PIAS2 PIBF1 PKP2 PLEKHA7 POLD2 POLR2C POU6F2 PPP1R13B PRDM6 PRKCG PROSER3 RABGEF1 RALBP1 RBM17 RBM41 RCOR3 RINT1 RUSC1 SAMD11 SAT1 SMARCE1 SORBS3 SPAG5 SPG21 SSX2IP STAR STARD4 STMN2 STX11 SYCE1 SYCE1L TACC3 TADA2A TEKT1 TEX9 TFIP11 TPM1 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TRIM54 TRIML2 TSG101 TSGA10 TSHZ3 TXLNA TXLNB USHBP1 VPS52 VPS9D1 WASHC3 ZBTB16 ZFYVE19 ZGPAT ZNF620 ZNF629 ZNF655 ZNF774 ZRANB1 ZWINT	73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655
Entrez ID		54535	53615
HPRD ID		05607	04653
Ensembl ID		ENSG00000204536	ENSG00000071655
Uniprot IDs		A0A1U9X7G6 B0S7V6 B4DIA2 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31	O95983
PDB IDs			2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?		Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Microtubule-based Process Centrosome Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Organelle Organization Structural Constituent Of Skin Epidermis Centriolar Satellite Keratin Filament Intermediate Filament Structural Molecule Activity Cytoplasm Spindle Pole Cytoskeleton-dependent Intracellular Transport Organelle Localization Microtubule Organizing Center Organization Microtubule Microtubule-based Transport Microtubule Cytoskeleton Organization Cytosol Flemming Body Transport Along Microtubule Microtubule-based Movement Organelle Assembly Protein Localization To Centrosome Identical Protein Binding Microtubule Binding Centrosome Cycle Protein Localization To Cytoskeleton Signaling Adaptor Activity Establishment Of Localization In Cell Intracellular Transport Cell Division Centriole Regulation Of Microtubule Cytoskeleton Organization Epithelial Cell Differentiation Cellular Localization Microtubule Organizing Center Cilium Assembly Ciliary Basal Body Structural Constituent Of Cytoskeleton Establishment Of Organelle Localization Vesicle Tethering Involved In Exocytosis Axonemal A Tubule Inner Sheath Thioesterase Binding Syntaxin Binding	NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification
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