CCHCR1 and TRAF4

Number of citations of the paper that reports this interaction (PMID 12023963)
16

Data Source:
HPRD (two hybrid)

		CCHCR1	TRAF4
Gene Name		coiled-coil alpha-helical rod protein 1	TNF receptor-associated factor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centriole	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Tight Junction Perinuclear Region Of Cytoplasm
	Molecular Function		DNA Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding WW Domain Binding
	Biological Process	Protein Export From Nucleus Multicellular Organismal Development Cell Differentiation	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Protein Ubiquitination Respiratory Tube Development Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Protein Homodimerization Activity
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Hematology traits ( 23263863) Nevirapine-induced rash ( 21810746) Prostate cancer ( 21743467) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) White blood cell count ( 21738480)
Protein-Protein Interactions		57 interactors: ABI2 ALAS1 AMOTL2 ATG5 BLOC1S6 C1orf94 CARD9 CCDC102B CCDC136 CCDC53 CDR2 CEP55 CTAGE5 DTNBP1 EFHC2 FSD2 GOLGA2 HAUS1 HSBP1 IKBKG KRT13 KRT15 KRT31 KRT40 MAD1L1 MED4 MID2 MTUS2 NAB2 NDC80 NDEL1 NINL NME7 NUP62 NUTM1 PIAS2 POLD2 POLR2C PRKCG RBM17 SAT1 SPAG5 SSX2IP STAR TADA2A TEKT1 TFIP11 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TSGA10 TXLNA TXLNB USHBP1 ZFYVE19	69 interactors: ALKBH4 ARNT2 BAHD1 BANP BCKDK BCL6B BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FBXL18 FTH1 GORASP2 GPRASP1 HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGED1 MAP3K4 MRPL28 NCF1 NGFR NGFRAP1 NOS1AP NPAS2 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581
Entrez ID		54535	9618
HPRD ID		05607	03915
Ensembl ID		ENSG00000204536	ENSG00000076604
Uniprot IDs		B0S7V6 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31	Q9BUZ4
PDB IDs			2EOD 2YUC 4M4E
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Mitotic Cell Cycle Process Microtubule-based Transport Activation Of NF-kappaB-inducing Kinase Activity Cytoskeleton-dependent Intracellular Transport Organelle Organization Positive Regulation Of NIK/NF-kappaB Signaling Cell Cycle Process NIK/NF-kappaB Signaling Mitotic Nuclear Division Cell Cycle Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Microtubule-based Process Positive Regulation Of NF-kappaB Transcription Factor Activity Axon Cargo Transport Innate Immune Response Cell Division Positive Regulation Of Protein Homodimerization Activity Cytoskeleton Organization Microtubule-based Movement Establishment Of Organelle Localization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Release From Host Cell Establishment Of Vesicle Localization Intracellular Receptor Signaling Pathway Anterograde Synaptic Vesicle Transport Negative Regulation Of Neuron Death Vesicle Localization Regulation Of Protein Homodimerization Activity Centrosome Organization Negative Regulation Of Viral Transcription Melanosome Organization Establishment Of Localization In Cell Pigment Granule Organization Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Developmental Process Organelle Localization Microtubule Organizing Center Organization Cellular Localization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Anterograde Axon Cargo Transport Regulation Of Apoptotic Process Microtubule Cytoskeleton Organization Positive Regulation Of JNK Cascade Spindle Organization Regulation Of Cell Death	Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Signaling Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Response To Cytokine Cellular Protein Catabolic Process Cell Death Death Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process
Tagcloud ?			bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Difference) ?			bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Intersection) ?