CLSPN and RAD9A

Number of citations of the paper that reports this interaction (PMID 12766152)
59

Data Source:
HPRD (in vivo, in vitro)

		CLSPN	RAD9A
Gene Name		claspin	RAD9 homolog A (S. pombe)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function	DNA Binding Protein Binding Anaphase-promoting Complex Binding	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Peptidyl-serine Phosphorylation G2 DNA Damage Checkpoint Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint	DNA Replication Checkpoint DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Apoptotic cleavage of cellular proteins G2/M Checkpoints Activation of ATR in response to replication stress Programmed Cell Death Apoptotic execution phase Cell Cycle Checkpoints	G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATR BRCA1 CASP7 CDC7 CHEK1 FZR1 RAD9A USP28 USP29 USP7	27 interactors: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CHEK2 CLSPN COPS5 DNAJC7 FEM1B HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 PCNA RAD17 RAD9B RPA1 RPA2 SF3B3 TOPBP1
Entrez ID		63967	5883
HPRD ID		09257	04788
Ensembl ID		ENSG00000092853	ENSG00000172613
Uniprot IDs		Q9HAW4	Q99638
PDB IDs			3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Metabolic Process Cellular Response To Stress Cell Cycle Process DNA Replication Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Response To DNA Damage Stimulus Cell Cycle Regulation Of Protein Metabolic Process Cellular Response To Radiation Response To Ionizing Radiation G2 DNA Damage Checkpoint Response To Radiation Regulation Of Histone H3-K9 Acetylation Cellular Response To UV Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Cellular Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Light Stimulus Response To Stress Protein Deubiquitination Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Cell Cycle Response To UV Replicative Senescence Double-strand Break Repair Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Response To Abiotic Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Mismatch Repair Cell Cycle Process DNA Metabolic Process Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle DNA Recombination Response To Stress Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Process Response To Ionizing Radiation Heterocycle Metabolic Process Double-strand Break Repair Cellular Nitrogen Compound Metabolic Process Meiotic Mismatch Repair Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Regulation Of DNA Recombination Cellular Response To Stimulus B Cell Activation Response To Radiation DNA Replication Positive Regulation Of Helicase Activity Meiotic Nuclear Division Somatic Recombination Of Immunoglobulin Gene Segments Apoptotic Process Somatic Diversification Of Immunoglobulins Programmed Cell Death Mitotic DNA Integrity Checkpoint Cell Death Meiotic Cell Cycle Death Meiosis I Response To Abiotic Stimulus B Cell Activation Involved In Immune Response Somatic Hypermutation Of Immunoglobulin Genes
Tagcloud ?		aplp1 attempted bioinformatics candidates carcinogenic carcinogenicity cav1 comet cytoprotective fosl2 functioned h2ax imbalance lethal mica mutagenicity nickel nrf2 pcaf pim2 prame principally qrt redox regarded runx1 slc7a6 synergistic toxicants	11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy
Tagcloud (Difference) ?		aplp1 attempted bioinformatics candidates carcinogenic carcinogenicity cav1 comet cytoprotective fosl2 functioned h2ax imbalance lethal mica mutagenicity nickel nrf2 pcaf pim2 prame principally qrt redox regarded runx1 slc7a6 synergistic toxicants	11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy
Tagcloud (Intersection) ?