CLSPN and USP28

Number of citations of the paper that reports this interaction (PMID 16901786)
62

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CLSPN	USP28
Gene Name		claspin	ubiquitin specific peptidase 28
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Nucleolus Protein Complex
	Molecular Function	DNA Binding Protein Binding Anaphase-promoting Complex Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Peptidyl-serine Phosphorylation G2 DNA Damage Checkpoint Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Apoptotic cleavage of cellular proteins G2/M Checkpoints Activation of ATR in response to replication stress Programmed Cell Death Apoptotic execution phase Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATR BRCA1 CASP7 CDC7 CHEK1 FZR1 RAD9A USP28 USP29 USP7	33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		63967	57646
HPRD ID		09257	15632
Ensembl ID		ENSG00000092853	ENSG00000048028
Uniprot IDs		Q9HAW4	B4E3L3 Q96RU2
PDB IDs			2LVA
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Metabolic Process Cellular Response To Stress Cell Cycle Process DNA Replication Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Response To DNA Damage Stimulus Cell Cycle Regulation Of Protein Metabolic Process Cellular Response To Radiation Response To Ionizing Radiation G2 DNA Damage Checkpoint Response To Radiation Regulation Of Histone H3-K9 Acetylation Cellular Response To UV Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Cellular Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Light Stimulus Response To Stress Protein Deubiquitination Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Cell Cycle Response To UV Replicative Senescence Double-strand Break Repair Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Response To Abiotic Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		aplp1 attempted bioinformatics candidates carcinogenic carcinogenicity cav1 comet cytoprotective fosl2 functioned h2ax imbalance lethal mica mutagenicity nickel nrf2 pcaf pim2 prame principally qrt redox regarded runx1 slc7a6 synergistic toxicants	acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Difference) ?		aplp1 attempted bioinformatics candidates carcinogenic carcinogenicity cav1 comet cytoprotective fosl2 functioned h2ax imbalance lethal mica mutagenicity nickel nrf2 pcaf pim2 prame principally qrt redox regarded runx1 slc7a6 synergistic toxicants	acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Intersection) ?