RAD9A and RHNO1

Number of citations of the paper that reports this interaction (PubMedID 31776186)
25

Data Source:
BioGRID (pull down)

		RAD9A	RHNO1
Description		RAD9 checkpoint clamp component A	RAD9-HUS1-RAD1 interacting nuclear orphan 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Chromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Protein Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	DNA Damage Checkpoint Signaling Recombinational Repair DNA Repair Chromatin Organization DNA Damage Response Cellular Response To UV Positive Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation Double-strand Break Repair Via Alternative Nonhomologous End Joining Protein Localization To Site Of Double-strand Break
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN	11 interacting genes: BANP CYSRT1 GOLGA2 HUS1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LZTS2 RAD1 RAD9A TFIP11
Entrez ID		5883	83695
HPRD ID		04788	17487
Ensembl ID		ENSG00000172613	ENSG00000171792
Uniprot IDs		Q99638	Q9BSD3
PDB IDs		3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8	6J8Y 8WU8
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint	Checkpoint Clamp Complex Double-stranded DNA 3'-5' DNA Exonuclease Activity Cellular Response To Ionizing Radiation Meiotic Cell Cycle Checkpoint Signaling Keratin Filament DNA Damage Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Intermediate Filament Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Primary Ureteric Bud Growth Mitotic DNA Integrity Checkpoint Signaling DNA Metabolic Process Mitotic DNA Damage Checkpoint Signaling DNA Damage Response Negative Regulation Of Cell Cycle Meiotic DNA Integrity Checkpoint Signaling Spliceosomal Complex Disassembly Telomere Maintenance Meiotic Recombination Checkpoint Signaling U2-type Post-mRNA Release Spliceosomal Complex Response To Radiation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Glycosylation Telomere Organization DNA Repair Golgi Disassembly Regulation Of Protein Glycosylation Protection From Non-homologous End Joining At Telomere Ureter Morphogenesis Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Importin-alpha Family Protein Binding Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Severing Golgi Ribbon Formation Mitotic DNA Replication Checkpoint Signaling Golgi Cis Cisterna Negative Regulation Of Mitotic Cell Cycle Spindle Midzone Assembly
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