RAD9A and MSH2

Number of citations of the paper that reports this interaction (PMID 20188637)
8

Data Source:
BioGRID (far western blotting)

		RAD9A	MSH2
Gene Name		RAD9 homolog A (S. pombe)	mutS homolog 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Nuclear Chromosome Nucleoplasm Membrane MutSalpha Complex MutSbeta Complex
	Molecular Function	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Meiotic Mismatch Repair In Utero Embryonic Development Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Meiotic Gene Conversion Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Negative Regulation Of Reciprocal Meiotic Recombination Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CHEK2 CLSPN COPS5 DNAJC7 FEM1B HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 PCNA RAD17 RAD9B RPA1 RPA2 SF3B3 TOPBP1	25 interactors: ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP ESR1 ESR2 EXO1 GRB7 HUS1 MAX MSH3 MSH6 PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 TK1 TREX1 XPA
Entrez ID		5883	4436
HPRD ID		04788	00389
Ensembl ID		ENSG00000172613	ENSG00000095002
Uniprot IDs		Q99638	E9PHA6 P43246
PDB IDs		3A1J 3G65 3GGR	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Mismatch Repair Cell Cycle Process DNA Metabolic Process Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle DNA Recombination Response To Stress Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Process Response To Ionizing Radiation Heterocycle Metabolic Process Double-strand Break Repair Cellular Nitrogen Compound Metabolic Process Meiotic Mismatch Repair Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Regulation Of DNA Recombination Cellular Response To Stimulus B Cell Activation Response To Radiation DNA Replication Positive Regulation Of Helicase Activity Meiotic Nuclear Division Somatic Recombination Of Immunoglobulin Gene Segments Apoptotic Process Somatic Diversification Of Immunoglobulins Programmed Cell Death Mitotic DNA Integrity Checkpoint Cell Death Meiotic Cell Cycle Death Meiosis I Response To Abiotic Stimulus B Cell Activation Involved In Immune Response Somatic Hypermutation Of Immunoglobulin Genes	DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Damage Checkpoint Cell Cycle Process Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Ionizing Radiation Response To Abiotic Stimulus DNA Replication Negative Regulation Of DNA Metabolic Process Response To Stimulus Mismatch Repair Cellular Response To Ionizing Radiation Cellular Response To Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Catabolic Process, Exonucleolytic Negative Regulation Of DNA Replication Regulation Of DNA Replication Response To UV Developmental Process DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Checkpoint Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Meiotic Cell Cycle Cellular Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Meiotic Mismatch Repair Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins
Tagcloud ?		11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy	adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Difference) ?		11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy	adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Intersection) ?