RAD9A and CAD

Number of citations of the paper that reports this interaction (PubMedID 15326225)
32

Data Source:
BioGRID (pull down)

		RAD9A	CAD
Description		RAD9 checkpoint clamp component A	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Nucleus Cytoplasm Cytosol Membrane Nuclear Matrix Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Extracellular Exosome
	Molecular Function	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Nucleotide Binding Catalytic Activity Aspartate Carbamoyltransferase Activity Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Dihydroorotase Activity Glutaminase Activity Protein Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Amino Acid Binding Transferase Activity Carboxyl- Or Carbamoyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Ligase Activity Enzyme Binding Identical Protein Binding Metal Ion Binding Aspartate Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Liver Development 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UDP Biosynthetic Process UTP Biosynthetic Process Amino Acid Metabolic Process Glutamine Metabolic Process Phosphate-containing Compound Metabolic Process Xenobiotic Metabolic Process Heart Development Female Pregnancy Lactation Response To Amine Citrulline Biosynthetic Process Response To Caffeine Animal Organ Regeneration Response To Insulin Response To Testosterone Response To Starvation 'de Novo' UMP Biosynthetic Process Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Pyrimidine-containing Compound Biosynthetic Process
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Pyrimidine biosynthesis
Drugs			Sparfosic acid
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Triglyceride levels ( 32203549)
Interacting Genes		39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN	13 interacting genes: CASP3 CEBPA HTRA2 MAPK1 NEDD4 PPP1CA PPP2CA PRKACA PTEN RAD9A SUMO2 XIAP YWHAG
Entrez ID		5883	790
HPRD ID		04788	06437
Ensembl ID		ENSG00000172613	ENSG00000084774
Uniprot IDs		Q99638	F8VPD4 P27708
PDB IDs		3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8	4BY3 4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q 5G1N 5G1O 5G1P 5YNZ 6HFD 6HFE 6HFF 6HFH 6HFI 6HFJ 6HFK 6HFL 6HFN 6HFP 6HFQ 6HFR 6HFS 6HFU 6HG1 8GVZ 8GW0 8PBE 8PBG 8PBH 8PBI 8PBJ 8PBK 8PBM 8PBN 8PBP 8PBQ 8PBR 8PBS 8PBT 8PBU 9FS1 9FS2 9FS3
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint	Cellular Response To Stress Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Signal Transduction DNA Damage Response Execution Phase Of Apoptosis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Phosphate Metabolic Process Regulation Of Protein Stability Positive Regulation Of Signal Transduction Regulation Of Macroautophagy Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Nucleus Protein Domain Specific Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Protein Catabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Positive Regulation Of Metabolic Process Learning Or Memory Glutamatergic Synapse Regulation Of Phosphorus Metabolic Process Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Regulation Of Gene Expression Cognition Response To Lead Ion
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