CLSPN and FZR1

Number of citations of the paper that reports this interaction (PMID 18662541)
98

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		CLSPN	FZR1
Gene Name		claspin	fizzy/cell division cycle 20 related 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding Anaphase-promoting Complex Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Peptidyl-serine Phosphorylation G2 DNA Damage Checkpoint Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint	Mitotic Cell Cycle DNA Repair Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Regulation Of Meiosis Positive Regulation Of Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Negative Regulation Of Cell Aging
Pathways		Apoptotic cleavage of cellular proteins G2/M Checkpoints Activation of ATR in response to replication stress Programmed Cell Death Apoptotic execution phase Cell Cycle Checkpoints	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Cellular Senescence Phosphorylation of Emi1 Orc1 removal from chromatin Autodegradation of Cdh1 by Cdh1:APC/C Class I MHC mediated antigen processing & presentation Removal of licensing factors from origins Switching of origins to a post-replicative state Synthesis of DNA Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Orc1 removal from chromatin SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Cyclin A:Cdk2-associated events at S phase entry Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATR BRCA1 CASP7 CDC7 CHEK1 FZR1 RAD9A USP28 USP29 USP7	42 interactors: ANAPC1 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B C7orf25 CCNA2 CCNB1 CDC14A CDC20 CDC25A CDC27 CDC6 CDK1 CDK2 CDR2 CDT1 CLSPN DNAJA1 E2F3 FBXO5 HECW2 MAK MAPK8 MOAP1 PLK1 PTEN PTTG1 RBBP8 SIRT2 SKIL SKP2 SOX2 TK1 TP53 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2S
Entrez ID		63967	51343
HPRD ID		09257	04687
Ensembl ID		ENSG00000092853
Uniprot IDs		Q9HAW4	Q9UM11
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Metabolic Process Cellular Response To Stress Cell Cycle Process DNA Replication Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Response To DNA Damage Stimulus Cell Cycle Regulation Of Protein Metabolic Process Cellular Response To Radiation Response To Ionizing Radiation G2 DNA Damage Checkpoint Response To Radiation Regulation Of Histone H3-K9 Acetylation Cellular Response To UV Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Cellular Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Light Stimulus Response To Stress Protein Deubiquitination Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Cell Cycle Response To UV Replicative Senescence Double-strand Break Repair Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Response To Abiotic Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Regulation Of Chromosome Segregation Mitotic Nuclear Division Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Division Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Checkpoint Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Cellular Macromolecule Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Chromosome Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		aplp1 attempted bioinformatics candidates carcinogenic carcinogenicity cav1 comet cytoprotective fosl2 functioned h2ax imbalance lethal mica mutagenicity nickel nrf2 pcaf pim2 prame principally qrt redox regarded runx1 slc7a6 synergistic toxicants	anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion
Tagcloud (Difference) ?		aplp1 attempted bioinformatics candidates carcinogenic carcinogenicity cav1 comet cytoprotective fosl2 functioned h2ax imbalance lethal mica mutagenicity nickel nrf2 pcaf pim2 prame principally qrt redox regarded runx1 slc7a6 synergistic toxicants	anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion
Tagcloud (Intersection) ?