CLSPN and TIPIN

Number of citations of the paper that reports this interaction (PubMedID 20233725)
65

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CLSPN	TIPIN
Description		claspin	TIMELESS interacting protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Chromatin Nucleus Nucleoplasm Cytoplasm Replication Fork Protection Complex
	Molecular Function	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding	DNA Binding Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Damage Response Positive Regulation Of Cell Population Proliferation Response To UV Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Regulation Of Nuclear Cell Cycle DNA Replication Replication Fork Arrest Cell Cycle Phase Transition Cell Division
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends	Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Adult body size ( 32376654) Testicular germ cell tumor ( 28604728 28604732)
Interacting Genes		20 interacting genes: ATR BRCA1 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7	5 interacting genes: APP CLSPN GSC2 TEX11 TIMELESS
Entrez ID		63967	54962
HPRD ID		09257	16917
Ensembl ID		ENSG00000092853	ENSG00000075131
Uniprot IDs		Q9HAW4	B4DRF3 Q9BVW5
PDB IDs		7AKO 7PFO 7PLO 8B9D	7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling	DNA Replication Checkpoint Signaling Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine DNA Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Replication Fork Arrest DNA Metabolic Process Replication Fork Protection Complex Cellular Response To Cisplatin Cellular Response To Bleomycin Gene Conversion Male Meiosis Chromosome Segregation Meiotic Gene Conversion DNA Secondary Structure Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Bleomycin Negative Regulation Of Cell Cycle Phase Transition Response To Cisplatin Chiasma Assembly Axon Choice Point Recognition Regulation Of Cell Cycle Heparan Sulfate Binding Signaling Receptor Activator Activity
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