RAD9A and MSH3

Number of citations of the paper that reports this interaction (PMID 20188637)
8

Data Source:
BioGRID (far western blotting)

		RAD9A	MSH3
Gene Name		RAD9 homolog A (S. pombe)	mutS homolog 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Nuclear Chromosome Nucleus Nucleoplasm Membrane MutSbeta Complex
	Molecular Function	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Centromeric DNA Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Meiotic Mismatch Repair DNA Repair Mismatch Repair Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CHEK2 CLSPN COPS5 DNAJC7 FEM1B HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 PCNA RAD17 RAD9B RPA1 RPA2 SF3B3 TOPBP1	12 interactors: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 XPA
Entrez ID		5883	4437
HPRD ID		04788	02931
Ensembl ID		ENSG00000172613	ENSG00000113318
Uniprot IDs		Q99638	A1L480 P20585
PDB IDs		3A1J 3G65 3GGR	3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Mismatch Repair Cell Cycle Process DNA Metabolic Process Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle DNA Recombination Response To Stress Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Process Response To Ionizing Radiation Heterocycle Metabolic Process Double-strand Break Repair Cellular Nitrogen Compound Metabolic Process Meiotic Mismatch Repair Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Regulation Of DNA Recombination Cellular Response To Stimulus B Cell Activation Response To Radiation DNA Replication Positive Regulation Of Helicase Activity Meiotic Nuclear Division Somatic Recombination Of Immunoglobulin Gene Segments Apoptotic Process Somatic Diversification Of Immunoglobulins Programmed Cell Death Mitotic DNA Integrity Checkpoint Cell Death Meiotic Cell Cycle Death Meiosis I Response To Abiotic Stimulus B Cell Activation Involved In Immune Response Somatic Hypermutation Of Immunoglobulin Genes	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress DNA Recombination Cell Cycle DNA Damage Checkpoint Cell Cycle Process Cell Cycle Checkpoint DNA Replication Response To Ionizing Radiation Response To Stress Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Radiation Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Postreplication Repair Isotype Switching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments DNA Catabolic Process DNA Catabolic Process, Exonucleolytic Double-strand Break Repair Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Nitrogen Compound Metabolic Process B Cell Activation Involved In Immune Response Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Meiotic Cell Cycle Cellular Response To Ionizing Radiation Immunoglobulin Production Protein K6-linked Ubiquitination Response To Abiotic Stimulus Cellular Response To Stimulus Intra-S DNA Damage Checkpoint Mitotic Cell Cycle Process Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Apoptotic Signaling Pathway Mitotic Cell Cycle Response To UV Cellular Metabolic Process
Tagcloud ?		11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy	addressed aom apc apex1 azoxymethane carcinogenesis colorectal crc dextran dss epi experimentally expressions mgmt mismatch mlh1 mlh3 mmr pilot pms1 pms2 precancerous prerequisite rectum sacrificed sequential sigmoid sulphate suppressor
Tagcloud (Difference) ?		11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy	addressed aom apc apex1 azoxymethane carcinogenesis colorectal crc dextran dss epi experimentally expressions mgmt mismatch mlh1 mlh3 mmr pilot pms1 pms2 precancerous prerequisite rectum sacrificed sequential sigmoid sulphate suppressor
Tagcloud (Intersection) ?