CLSPN and USP29

Number of citations of the paper that reports this interaction (PubMedID 24632611)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CLSPN	USP29
Description		claspin	ubiquitin specific peptidase 29
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling	G1/S Transition Of Mitotic Cell Cycle Immune System Process Proteolysis Protein Deubiquitination Regulation Of Protein Stability Innate Immune Response Protein Stabilization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Deubiquitination
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Urate levels in lean individuals ( 25811787)
Interacting Genes		20 interacting genes: ATR BRCA1 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7	5 interacting genes: CLSPN CTDSP1 HRAS MAP3K7 SNAI1
Entrez ID		63967	57663
HPRD ID		09257	07163
Ensembl ID		ENSG00000092853	ENSG00000131864
Uniprot IDs		Q9HAW4	A1L447 Q9HBJ7
PDB IDs		7AKO 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling	Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Phospholipase C Activator Activity T Cell Receptor Signaling Pathway Regulation Of Primary Metabolic Process Oncogene-induced Cell Senescence Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Motility Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle GTPase Complex MAPK Cascade Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding Signal Transduction In Response To DNA Damage MAP Kinase Kinase Kinase Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Histone Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Mitotic Cell Cycle DNA Secondary Structure Binding Regulation Of Locomotion Positive Regulation Of CGAS/STING Signaling Pathway Interleukin-33-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Ruffle Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process T-helper 1 Type Immune Response Immune Response-activating Signaling Pathway Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Trophoblast Giant Cell Differentiation Heterochromatin Organization Left/right Pattern Formation Cartilage Morphogenesis Regulation Of Vitamin Metabolic Process Positive Regulation Of Phosphate Metabolic Process
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