RAD9A and RPA1

Number of citations of the paper that reports this interaction (PubMedID 18936170)
50

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		RAD9A	RPA1
Description		RAD9 checkpoint clamp component A	replication protein A1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Nuclear Chromosome Chromosome, Telomeric Region Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination Chromatin Organization DNA Damage Response Telomere Maintenance Via Telomerase Positive Regulation Of Cell Population Proliferation Hemopoiesis Protein Localization To Chromosome Homeostasis Of Number Of Cells Within A Tissue Chromosome Organization Meiotic Cell Cycle Protein Localization To Site Of Double-strand Break
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN	70 interacting genes: AICDA AJUBA AKTIP ASCC2 ATM ATR BLM BRCA2 BRIP1 CCNA1 CEBPA CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 GNB5 GRB2 HAX1 HELB HGH1 HIRA HNRNPUL1 HSPA6 HUS1 KAT2A KAT2B MCM2 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RECQL RFWD3 RIPK1 RNF20 RNF40 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WAS WRN XPA XPC ZBTB14
Entrez ID		5883	6117
HPRD ID		04788	01565
Ensembl ID		ENSG00000172613	ENSG00000132383
Uniprot IDs		Q99638	P27694
PDB IDs		3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8	1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A 7XUT 7XUV 7XUW 7XV0 7XV1 7XV4 8JZV 8JZY 8K00 8RK2 9J1S 9MJ5
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint	DNA Metabolic Process DNA Repair DNA Damage Response DNA Recombination Cellular Response To Stress Double-strand Break Repair Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction In Response To DNA Damage Macromolecule Metabolic Process Single-stranded DNA Binding Cellular Response To Radiation Nucleoplasm DNA Replication Nucleotide-excision Repair DNA Damage Checkpoint Signaling Response To Ionizing Radiation Response To Radiation Site Of Double-strand Break Replication Fork Processing Chromosome, Telomeric Region Chromosome Organization Cellular Response To Ionizing Radiation Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Telomere Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Mismatch Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Response To UV Regulation Of Cellular Response To Stress DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding DNA Replication Factor A Complex MutLalpha Complex Binding Response To Gamma Radiation Mitotic Recombination DNA Helicase Activity
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