CLSPN and CSNK1G3

Number of citations of the paper that reports this interaction (PubMedID 21680713)
44

Data Source:
BioGRID (enzymatic study)

		CLSPN	CSNK1G3
Description		claspin	casein kinase 1 gamma 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling	Endocytosis Signal Transduction Wnt Signaling Pathway Protein Modification Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs			Purvalanol A {4-Amino-2-[(4-methoxyphenyl)amino]-1,3-thiazol-5-yl}(4-methoxyphenyl)methanone 4-Amino-2-[(3-chlorophenyl)amino]-5-(4-fluorobenzoyl)-1,3-thiazol-3-ium K-00546
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Adult asthma ( 27611488) Amyotrophic lateral sclerosis ( 19451621) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Chronotype ( 30696823) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diastolic blood pressure ( 30578418 27618452) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Nickel levels ( 26025379) Pulse pressure ( 27618448) Rapid response to perioperative phenylephrine (change in systolic blood pressure) ( 33168928) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618452) Total body bone mineral density ( 29304378) Total cholesterol levels ( 28334899) Virologic severity in Herpes simplex virus type 2 infection ( 29535370)
Interacting Genes		20 interacting genes: ATR BRCA1 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7	7 interacting genes: CLSPN DBNDD2 DRICH1 KRTAP10-10 MDFI PPP1R14A SNCA
Entrez ID		63967	1456
HPRD ID		09257	05034
Ensembl ID		ENSG00000092853	ENSG00000151292
Uniprot IDs		Q9HAW4	A0A8V8TKT3 Q9Y6M4
PDB IDs		7AKO 7PFO 7PLO 8B9D	2CHL 2IZR 2IZS 2IZT 2IZU 4G16 4G17 4HGL 4HGS 6GRO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling	Protein Sequestering Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Phosphorus Metabolic Process Transporter Regulator Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake DNA Secondary Structure Binding Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process
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