CLSPN and CSNK1G2

Number of citations of the paper that reports this interaction (PubMedID 21680713)
44

Data Source:
BioGRID (enzymatic study)

		CLSPN	CSNK1G2
Description		claspin	casein kinase 1 gamma 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane
	Molecular Function	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Sphingolipid Biosynthetic Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends	Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs			IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Body mass index ( 25673413) Coronary artery disease ( 29212778) Periodontitis (stage III/IV grade C) ( 33745150) Red cell distribution width ( 27863252 32888494) Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		20 interacting genes: ATR BRCA1 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7	17 interacting genes: APP APPBP2 CERT1 CLSPN DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 OGT PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 SNCA WDCP
Entrez ID		63967	1455
HPRD ID		09257	03738
Ensembl ID		ENSG00000092853	ENSG00000133275
Uniprot IDs		Q9HAW4	P78368
PDB IDs		7AKO 7PFO 7PLO 8B9D	2C47
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling	Regulation Of Cell Junction Assembly Regulation Of Phosphorus Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Presynapse Organization Insulin Receptor Binding Chemical Homeostasis Negative Regulation Of RNA Biosynthetic Process Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Ephrin Receptor Binding Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process Regulation Of Presynapse Assembly Negative Regulation Of DNA-templated Transcription Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Copper Ion Chromatin DNA Binding Negative Regulation Of Protein Catabolic Process Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Circadian Rhythm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microglial Cell Activation Regulation Of Protein Catabolic Process Regulation Of Supramolecular Fiber Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of Synapse Assembly Response To Copper Ion Positive Regulation Of Endocytosis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Locomotory Behavior Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein Kinase Inhibitor Activity
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