ZNF335 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		ZNF335	HSPB2
Description		zinc finger protein 335	heat shock protein family B (small) member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone Methyltransferase Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Brain Development Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Cerebral Cortex Neuron Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Brain Morphogenesis Positive Regulation Of Lymphocyte Proliferation Regulation Of Neurogenesis Positive Regulation Of Neurogenesis	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Celiac disease ( 25920553) Coronary artery disease ( 29212778 33020668) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CCAR2 CDK4 CDK6 HSPB2 NCOA6 USP7	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		63925	3316
HPRD ID		11709	03712
Ensembl ID		ENSG00000198026	ENSG00000170276
Uniprot IDs		Q8IW09 Q9H4Z2	A8KAH6 Q16082
PDB IDs			6F2R
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Unfolded Protein Binding Regulation Of Circadian Rhythm Negative Regulation Of Protein Catabolic Process DBIRD Complex Regulation Of DNA-templated Transcription Cyclin D2-CDK4 Complex Regulation Of RNA Biosynthetic Process Response To Stress Cellular Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cell Cycle Phase Transition Somatic Muscle Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA Damage Checkpoint Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Nucleus	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
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