ZNF335 and NCOA6

Number of citations of the paper that reports this interaction (PubMedID 12215545)
60

Data Source:
HPRD (in vitro, in vivo)

		ZNF335	NCOA6
Description		zinc finger protein 335	nuclear receptor coactivator 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone Methyltransferase Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Nuclear Estrogen Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Brain Development Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Cerebral Cortex Neuron Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Brain Morphogenesis Positive Regulation Of Lymphocyte Proliferation Regulation Of Neurogenesis Positive Regulation Of Neurogenesis	DNA-templated Transcription Initiation DNA Damage Response Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Cytoprotection by HMOX1 Heme signaling Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Celiac disease ( 25920553) Coronary artery disease ( 29212778 33020668) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CCAR2 CDK4 CDK6 HSPB2 NCOA6 USP7	63 interacting genes: AR ASCC1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XIAP XRCC5 XRCC6 ZNF335
Entrez ID		63925	23054
HPRD ID		11709	05599
Ensembl ID		ENSG00000198026	ENSG00000198646
Uniprot IDs		Q8IW09 Q9H4Z2	F6M2K2 F6M2K3 Q14686
PDB IDs
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Unfolded Protein Binding Regulation Of Circadian Rhythm Negative Regulation Of Protein Catabolic Process DBIRD Complex Regulation Of DNA-templated Transcription Cyclin D2-CDK4 Complex Regulation Of RNA Biosynthetic Process Response To Stress Cellular Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cell Cycle Phase Transition Somatic Muscle Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA Damage Checkpoint Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Nucleus	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Chromatin DNA Binding Hormone-mediated Signaling Pathway Transcription Cis-regulatory Region Binding Chromatin Binding Intracellular Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Lipid Regulation Of Primary Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Hormone Negative Regulation Of Biosynthetic Process
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