SH2D4A and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH2D4A	GRAP2
Description		SH2 domain containing 4A	GRB2 related adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Protein Binding Phosphatase Binding	Phosphotyrosine Residue Binding Protein Binding
	Biological Process		Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Regulation Of MAPK Cascade
Pathways			Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Co-stimulation by CD28 FLT3 Signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Fasting plasma glucose ( 32682390) Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		73 interacting genes: ALAS1 ARC BLOC1S2 CADPS CASK CCDC172 CCDC88B CDR2 CDR2L CEP70 CEP76 CFAP53 DBNL FCHO1 FCHSD2 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 GRAP2 GRB2 HCLS1 HMBOX1 HOOK2 HSF2BP IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MBD3L1 MEOX2 MORN3 MRFAP1 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PICK1 PLEKHG4 PNMA1 PRKAR1B PSTPIP1 RINT1 SH3GL1 SH3RF1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 TRIML2 TTC19 UBXN11 USHBP1 VPS52 WWOX YPEL2 YPEL3 ZBTB16 ZMYND12 ZNF655 ZNF774	78 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526
Entrez ID		63898	9402
HPRD ID		08340	05156
Ensembl ID		ENSG00000104611	ENSG00000100351
Uniprot IDs		Q9H788	B7Z8E3 B7Z8F8 O75791 Q6FI14
PDB IDs			5GJH
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Cytoskeleton Organization Centrosome Microtubule Cytoskeleton Organization Cytoskeleton Vesicle-mediated Transport Microtubule-based Process Regulation Of Cytoskeleton Organization Establishment Of Localization In Cell Positive Regulation Of Cytoskeleton Organization Identical Protein Binding Cytosol Intracellular Transport Organelle Organization	Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade SH2 Domain Binding Antigen Receptor-mediated Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Binding Positive Regulation Of Protein Modification Process Identical Protein Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Growth Factor Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Modification Process Lymphocyte Activation Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Immune Response-regulating Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor
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