SH2D4A and ARC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH2D4A	ARC
Description		SH2 domain containing 4A	activity regulated cytoskeleton associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Acrosomal Vesicle Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Actin Cytoskeleton Membrane Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Cell Projection Neuronal Cell Body Dendritic Spine Membrane Raft Synapse Postsynaptic Membrane Neuronal Ribonucleoprotein Granule Glutamatergic Synapse Virus-like Capsid Extracellular Vesicle
	Molecular Function	Protein Binding Phosphatase Binding	RNA Binding MRNA Binding Structural Molecule Activity Protein Binding
	Biological Process		Endocytosis Cytoskeleton Organization Endoderm Development Long-term Memory Anterior/posterior Pattern Specification Cell Migration Regulation Of Cell Morphogenesis Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission MRNA Transport Protein Homooligomerization Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Regulation Of Dendritic Spine Morphogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Intercellular Transport Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Synaptic Depression
Pathways			NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Fasting plasma glucose ( 32682390) Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Automobile speeding propensity ( 30643258)
Interacting Genes		73 interacting genes: ALAS1 ARC BLOC1S2 CADPS CASK CCDC172 CCDC88B CDR2 CDR2L CEP70 CEP76 CFAP53 DBNL FCHO1 FCHSD2 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 GRAP2 GRB2 HCLS1 HMBOX1 HOOK2 HSF2BP IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MBD3L1 MEOX2 MORN3 MRFAP1 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PICK1 PLEKHG4 PNMA1 PRKAR1B PSTPIP1 RINT1 SH3GL1 SH3RF1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 TRIML2 TTC19 UBXN11 USHBP1 VPS52 WWOX YPEL2 YPEL3 ZBTB16 ZMYND12 ZNF655 ZNF774	7 interacting genes: CSRP2 KRT15 S100P SH2D4A SPTBN4 TBX18 UBE3A
Entrez ID		63898	23237
HPRD ID		08340	12469
Ensembl ID		ENSG00000104611	ENSG00000198576
Uniprot IDs		Q9H788	Q7LC44
PDB IDs			6TN7 6TNQ 6TQ0 6YTU 7R1Z 7R23 8QF4 8QF5
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Cytoskeleton Organization Centrosome Microtubule Cytoskeleton Organization Cytoskeleton Vesicle-mediated Transport Microtubule-based Process Regulation Of Cytoskeleton Organization Establishment Of Localization In Cell Positive Regulation Of Cytoskeleton Organization Identical Protein Binding Cytosol Intracellular Transport Organelle Organization	Sperm Entry Positive Regulation Of Golgi Lumen Acidification Sinoatrial Node Cell Fate Commitment Phosphatase Binding Muscle Tissue Development Tissue Development Structural Constituent Of Cytoskeleton Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cellular PH Reduction Regulation Of Golgi Lumen Acidification Ureter Development RNA Polymerase II Transcription Repressor Complex Sinoatrial Node Cell Development Neural Plate Pattern Specification Sinoatrial Node Development Cardiac Muscle Cell Fate Commitment Regulation Of SA Node Cell Action Potential Neural Plate Anterior/posterior Regionalization Cytoskeletal Protein-membrane Anchor Activity Clustering Of Voltage-gated Sodium Channels Axon Hillock Cell Body Fiber Paranode Region Of Axon Spectrin
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