SH2D4A and SKAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SH2D4A	SKAP1
Description		SH2 domain containing 4A	src kinase associated phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Phosphatase Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding
	Biological Process		Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
Pathways
Drugs
Diseases
GWAS		Fasting plasma glucose ( 32682390) Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Body mass index ( 25673413 28892062) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epithelial ovarian cancer ( 25581431) Food allergy ( 29030101) Generalized epilepsy ( 22949513) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Keratoconus ( 33649486) Lean body mass ( 28552196) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Ovarian cancer ( 20852632) Peanut allergy ( 29030101) Pulse pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		73 interacting genes: ALAS1 ARC BLOC1S2 CADPS CASK CCDC172 CCDC88B CDR2 CDR2L CEP70 CEP76 CFAP53 DBNL FCHO1 FCHSD2 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 GRAP2 GRB2 HCLS1 HMBOX1 HOOK2 HSF2BP IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MBD3L1 MEOX2 MORN3 MRFAP1 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PICK1 PLEKHG4 PNMA1 PRKAR1B PSTPIP1 RINT1 SH3GL1 SH3RF1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 TRIML2 TTC19 UBXN11 USHBP1 VPS52 WWOX YPEL2 YPEL3 ZBTB16 ZMYND12 ZNF655 ZNF774	13 interacting genes: APP BLCAP DYNLL2 EEIG1 FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		63898	8631
HPRD ID		08340	05396
Ensembl ID		ENSG00000104611	ENSG00000141293
Uniprot IDs		Q9H788	Q86WV1 V9HW03
PDB IDs			1U5D
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Cytoskeleton Organization Centrosome Microtubule Cytoskeleton Organization Cytoskeleton Vesicle-mediated Transport Microtubule-based Process Regulation Of Cytoskeleton Organization Establishment Of Localization In Cell Positive Regulation Of Cytoskeleton Organization Identical Protein Binding Cytosol Intracellular Transport Organelle Organization	Ephrin Receptor Binding Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Membrane Raft T Cell Costimulation Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune System Process Signaling Receptor Binding Positive Regulation Of Cell Activation Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Signaling Receptor Activator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation Regulation Of Immune System Process Phospholipase Activator Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Scaffold Protein Binding Immune System Process Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Regulation Of T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Defense Response Protein Tyrosine Kinase Activity CD8 Receptor Binding Growth Factor Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway
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