SH2D4A and STAM2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SH2D4A	STAM2
Gene Name		SH2 domain containing 4A	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Phosphatase Binding	Protein Binding
	Biological Process	Negative Regulation Of Phosphatase Activity	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways			Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ALAS1 CASK CCDC172 CDR2 CEP70 CEP76 DBNL FSD2 GOLGA2 GRB2 HCLS1 HMBOX1 IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MTUS2 NECAB2 NINL NUTM1 PDE4DIP PNMA1 PPP1CB PSTPIP1 RINT1 SH3GL1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 UBXN11 USHBP1 VPS52 ZBTB16	34 interactors: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1
Entrez ID		63898	10254
HPRD ID		08340	05876
Ensembl ID		ENSG00000104611	ENSG00000115145
Uniprot IDs		Q9H788	O75886
PDB IDs			1X2Q 1X5B 2L0T
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of NK T Cell Differentiation G2/M Transition Of Mitotic Cell Cycle Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Granulocyte Differentiation Mitotic Cell Cycle Immune System Process Positive Regulation Of Cytoskeleton Organization Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cell Division Mitotic Cell Cycle Process Positive Regulation Of Cell-cell Adhesion Protein Complex Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Calcium Ion Import Actin Filament Organization Regulation Of T Cell Activation Cytoskeleton Organization Positive Regulation Of Cell Activation Protein K63-linked Ubiquitination Protein Trimerization Cellular Protein Complex Assembly Positive Regulation Of Immune System Process Regulation Of Organelle Organization Regulation Of Microtubule-based Process Positive Regulation Of Neutrophil Differentiation Spliceosomal Complex Disassembly Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Immune System Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Metabolic Process Regulation Of Lymphocyte Activation Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cellular Localization Cell Cycle Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length	Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Protein K48-linked Ubiquitination Protein Polyubiquitination Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Defense Response Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Catabolic Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress JAK-STAT Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Activation Of Innate Immune Response Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Toll-like Receptor 4 Signaling Pathway Regulation Of Signal Transduction Regulation Of ERBB Signaling Pathway Positive Regulation Of Innate Immune Response Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Signal Transduction Protein Autophosphorylation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Hypoxia
Tagcloud ?			adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating
Tagcloud (Difference) ?			adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating
Tagcloud (Intersection) ?