CCL5 and PF4

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		CCL5	PF4
Description		C-C motif chemokine ligand 5	platelet factor 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemokine Receptor Antagonist Activity CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Leukocyte Cell-cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of TOR Signaling Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Cytokine Positive Regulation Of Homotypic Cell-cell Adhesion Response To Tumor Necrosis Factor Chemokine (C-C Motif) Ligand 5 Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Host-mediated Suppression Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Monocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Monocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Blood Coagulation Neutrophil Chemotaxis Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Heparin Disaccharide I-S Heparin Disaccharide Iii-S	Drotrecogin alfa Heparin
Diseases
GWAS		Blood protein levels ( 30072576)	Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		55 interacting genes: ACKR1 ACKR2 ACKR4 APC BAG4 BCAR3 CCL11 CCL13 CCL16 CCL17 CCL2 CCL20 CCL21 CCL24 CCL25 CCL26 CCL27 CCL28 CCR1 CCR3 CCR4 CCR5 CHEK2 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 DPP4 EDC4 FZR1 GRB2 IGFBP7 KRAS PALB2 PF4 PHB1 PIGR PPBP PTPN1 RANGAP1 RELA SDC1 SDC4 SLC2A5 TGFB1 TRIP6 VCAN WT1 XCL1 XCL2	29 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SNCA SRGN THBD VCAN XCL1 XCL2
Entrez ID		6352	5196
HPRD ID		01751	01426
Ensembl ID		ENSG00000271503	ENSG00000163737
Uniprot IDs		A0A494C1Q1 D0EI67 P13501	P02776
PDB IDs		1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW 5CMD 5COY 5DNF 5L2U 5UIW 6AEZ 6C6D 6FGP 6LOG 6STK 7F1R 7O7F	1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Migration Cytokine Activity Leukocyte Chemotaxis Cell Motility Inflammatory Response Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Cytokine-mediated Signaling Pathway Immune Response Killing Of Cells Of Another Organism Defense Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Stress CXCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Signal Transduction Response To Other Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Extracellular Space Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Eosinophil Chemotaxis Mononuclear Cell Migration Extracellular Region Positive Regulation Of Locomotion Eosinophil Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Leukocyte Migration Neutrophil Chemotaxis Chemokine Receptor Binding C-C Chemokine Binding Neutrophil Migration Positive Regulation Of Leukocyte Migration	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Chemotaxis Antimicrobial Humoral Response Cytokine Activity Locomotion Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Humoral Immune Response Leukocyte Migration Cell Migration Extracellular Space Cell Motility Granulocyte Chemotaxis Killing Of Cells Of Another Organism Granulocyte Migration Myeloid Leukocyte Migration Cell Killing Inflammatory Response CCR Chemokine Receptor Binding Defense Response To Symbiont Extracellular Region Defense Response To Other Organism Response To External Biotic Stimulus Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Immune Response Positive Regulation Of Locomotion Response To Other Organism Positive Regulation Of Chemotaxis Defense Response Immune System Process Regulation Of Leukocyte Migration Eosinophil Chemotaxis Positive Regulation Of Cell Migration Eosinophil Migration Chemokine Receptor Binding Regulation Of Locomotion Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis CXCR Chemokine Receptor Binding Lymphocyte Migration Regulation Of Cell Motility Positive Regulation Of Calcium Ion Transport T Cell Migration Response To Stress Lymphocyte Chemotaxis
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