CCL5 and TRIP6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CCL5	TRIP6
Gene Name		chemokine (C-C motif) ligand 5	thyroid hormone receptor interactor 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Kinase Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Protein Homodimerization Activity Protein Self-association Chemokine Receptor Antagonist Activity	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Leukocyte Cell-cell Adhesion G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Activation Of Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Protein Kinase B Signaling Cellular Protein Complex Assembly Negative Regulation By Host Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Positive Regulation Of JAK-STAT Cascade Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Protein Tetramerization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Protein Tyrosine Kinase Activity Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotaxis Regulation Of Neuron Death Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS			Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		21 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR4 CCR5 CXCL8 DPP4 EDC4 GRB2 IGFBP7 PF4 PIGR RANGAP1 RELA SDC1 SDC4 SLC2A5 TRIP6 VCAN	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		6352	7205
HPRD ID		01751	04242
Ensembl ID		ENSG00000161570	ENSG00000087077
Uniprot IDs		D0EI67 P13501	F2ZC06 Q15654
PDB IDs		1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW	1X61 2DLO
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Organic Substance Chemotaxis Response To Organic Substance Locomotion Defense Response Response To External Stimulus Immune Response Cellular Response To Stimulus Response To Stimulus Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Migration Immune System Process Cell Motility Signaling Cell Communication Response To Stress Leukocyte Migration Positive Regulation Of Organelle Assembly Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Behavior Response To Lipid Regulation Of Chemotaxis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Locomotion Cell Chemotaxis Cellular Defense Response Glycosaminoglycan Catabolic Process Cytosolic Calcium Ion Homeostasis Chondroitin Sulfate Metabolic Process Regulation Of Behavior Movement Of Cell Or Subcellular Component Response To Abiotic Stimulus Positive Regulation Of Leukocyte Chemotaxis Pathogenesis Response To Radiation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Response To Bacterium	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?