CCL5 and CCL11

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL5	CCL11
Description		C-C motif chemokine ligand 5	C-C motif chemokine ligand 11
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemokine Receptor Antagonist Activity CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Leukocyte Cell-cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of TOR Signaling Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Cytokine Positive Regulation Of Homotypic Cell-cell Adhesion Response To Tumor Necrosis Factor Chemokine (C-C Motif) Ligand 5 Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Host-mediated Suppression Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Monocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Killing Of Cells Of Another Organism Response To Interleukin-13 Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Response To Interleukin-4
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs		Heparin Disaccharide I-S Heparin Disaccharide Iii-S	CAT-213
Diseases
GWAS		Blood protein levels ( 30072576)	Crohn's disease ( 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		55 interacting genes: ACKR1 ACKR2 ACKR4 APC BAG4 BCAR3 CCL11 CCL13 CCL16 CCL17 CCL2 CCL20 CCL21 CCL24 CCL25 CCL26 CCL27 CCL28 CCR1 CCR3 CCR4 CCR5 CHEK2 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 DPP4 EDC4 FZR1 GRB2 IGFBP7 KRAS PALB2 PF4 PHB1 PIGR PPBP PTPN1 RANGAP1 RELA SDC1 SDC4 SLC2A5 TGFB1 TRIP6 VCAN WT1 XCL1 XCL2	29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1
Entrez ID		6352	6356
HPRD ID		01751	03098
Ensembl ID		ENSG00000271503	ENSG00000172156
Uniprot IDs		A0A494C1Q1 D0EI67 P13501	P51671 Q6I9T4
PDB IDs		1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW 5CMD 5COY 5DNF 5L2U 5UIW 6AEZ 6C6D 6FGP 6LOG 6STK 7F1R 7O7F	1EOT 2EOT 2MPM 7SCS
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Migration Cytokine Activity Leukocyte Chemotaxis Cell Motility Inflammatory Response Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Cytokine-mediated Signaling Pathway Immune Response Killing Of Cells Of Another Organism Defense Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Stress CXCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Signal Transduction Response To Other Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Extracellular Space Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Eosinophil Chemotaxis Mononuclear Cell Migration Extracellular Region Positive Regulation Of Locomotion Eosinophil Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Leukocyte Migration Neutrophil Chemotaxis Chemokine Receptor Binding C-C Chemokine Binding Neutrophil Migration Positive Regulation Of Leukocyte Migration	Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cytokine Activity Humoral Immune Response Chemokine-mediated Signaling Pathway Cell Migration Leukocyte Chemotaxis Cell Motility Inflammatory Response Granulocyte Chemotaxis Granulocyte Migration Immune Response Leukocyte Migration Defense Response Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Immune System Process CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Cell Killing Response To External Biotic Stimulus Response To Other Organism Extracellular Space G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Neutrophil Migration CCR Chemokine Receptor Binding Response To Stress Extracellular Region Cell-cell Signaling Signaling Cell Communication Mononuclear Cell Migration Cellular Response To Lipopolysaccharide Signal Transduction Cellular Response To Molecule Of Bacterial Origin Chemokine Receptor Binding Response To Molecule Of Bacterial Origin CXCR3 Chemokine Receptor Binding Response To Lipopolysaccharide Cell Surface Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Calcium Ion Transport
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