CCL5 and IGFBP7

Number of citations of the paper that reports this interaction (PMID 12847218)
6

Data Source:
HPRD (in vitro)

		CCL5	IGFBP7
Gene Name		chemokine (C-C motif) ligand 5	insulin-like growth factor binding protein 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Kinase Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Protein Homodimerization Activity Protein Self-association Chemokine Receptor Antagonist Activity	Protein Binding Insulin-like Growth Factor Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Leukocyte Cell-cell Adhesion G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Activation Of Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Protein Kinase B Signaling Cellular Protein Complex Assembly Negative Regulation By Host Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Positive Regulation Of JAK-STAT Cascade Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Protein Tetramerization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Protein Tyrosine Kinase Activity Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotaxis Regulation Of Neuron Death Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Proliferation Response To Heat Response To Retinoic Acid Cellular Response To Hormone Stimulus Inner Ear Development Regulation Of Steroid Biosynthetic Process Response To Cortisol
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs		Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS			Age-related macular degeneration ( 21909106)
Protein-Protein Interactions		21 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR4 CCR5 CXCL8 DPP4 EDC4 GRB2 IGFBP7 PF4 PIGR RANGAP1 RELA SDC1 SDC4 SLC2A5 TRIP6 VCAN	11 interactors: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		6352	3490
HPRD ID		01751	04183
Ensembl ID		ENSG00000161570	ENSG00000163453
Uniprot IDs		D0EI67 P13501	Q16270
PDB IDs		1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Organic Substance Chemotaxis Response To Organic Substance Locomotion Defense Response Response To External Stimulus Immune Response Cellular Response To Stimulus Response To Stimulus Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Migration Immune System Process Cell Motility Signaling Cell Communication Response To Stress Leukocyte Migration Positive Regulation Of Organelle Assembly Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Behavior Response To Lipid Regulation Of Chemotaxis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Locomotion Cell Chemotaxis Cellular Defense Response Glycosaminoglycan Catabolic Process Cytosolic Calcium Ion Homeostasis Chondroitin Sulfate Metabolic Process Regulation Of Behavior Movement Of Cell Or Subcellular Component Response To Abiotic Stimulus Positive Regulation Of Leukocyte Chemotaxis Pathogenesis Response To Radiation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Response To Bacterium	Positive Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Behavior Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Secretion By Cell Response To Stress Positive Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Localization Regulation Of T Cell Migration Regulation Of Cell Migration Leukocyte Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Secretion Regulation Of Leukocyte Migration Positive Regulation Of Cell Division Regulation Of Locomotion Cell Activation Positive Regulation Of Behavior Regulation Of Cellular Component Movement Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Chemotaxis
Tagcloud ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft
Tagcloud (Difference) ?		adaptor amplifies antagonism bdl bile binder broad chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1 gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft
Tagcloud (Intersection) ?