RRBP1 and PCNT

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RRBP1	PCNT
Description		ribosome binding protein 1	pericentrin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ribosome Membrane	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite
	Molecular Function	RNA Binding Protein Binding Signaling Receptor Activity	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	Osteoblast Differentiation Translation Protein Transport	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways		Signaling by ALK fusions and activated point mutants	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		Radezolid
Diseases			Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Frontotemporal dementia (age at onset) ( 29724592) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) HDL cholesterol levels ( 32203549) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 33536631) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301)	Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)
Interacting Genes		7 interacting genes: ATF7IP ITSN1 KIF5B PCNT PRKD2 RNF10 SMAD9	55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1
Entrez ID		6238	5116
HPRD ID		11796	05804
Ensembl ID		ENSG00000125844	ENSG00000160299
Uniprot IDs		Q9P2E9	O95613
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Modification Of Synaptic Structure Stress Granule Disassembly Anterograde Neuronal Dense Core Vesicle Transport Ciliary Rootlet Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Transport Centriolar Satellite Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Cytoplasm Organization Cytolytic Granule Membrane Retrograde Neuronal Dense Core Vesicle Transport Anterograde Axonal Protein Transport Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Plus-end-directed Organelle Transport Along Microtubule Mitocytosis Dense Core Granule Cytoskeletal Transport Positive Regulation Of RNA Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Molecular Adaptor Activity Postsynaptic Endocytic Zone Positive Regulation Of Caveolin-mediated Endocytosis Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway	Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity
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